ZNRF2 (zinc and ring finger 2)

2018-07-01  

Identity

HGNC
LOCATION
7p14.3
LOCUSID
ALIAS
RNF202
FUSION GENES

Other Information

Locus ID:

NCBI: 223082
MIM: 612061
HGNC: 22316
Ensembl: ENSG00000180233

Variants:

dbSNP: 223082
ClinVar: 223082
TCGA: ENSG00000180233
COSMIC: ZNRF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180233ENST00000323037Q8NHG8
ENSG00000180233ENST00000323037A0A090N8Y8

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375518452023A pancancer analysis of the oncogenic role of ZNRF2 in human tumours.1
375518452023A pancancer analysis of the oncogenic role of ZNRF2 in human tumours.1
308117642019Long non-coding RNA TTN-AS1 facilitates tumorigenesis of papillary thyroid cancer through modulating the miR-153-3p/ZNRF2 axis.34
308117642019Long non-coding RNA TTN-AS1 facilitates tumorigenesis of papillary thyroid cancer through modulating the miR-153-3p/ZNRF2 axis.34
284167742017MicroRNA-100 suppresses human osteosarcoma cell proliferation and chemo-resistance via ZNRF2.11
284167742017MicroRNA-100 suppresses human osteosarcoma cell proliferation and chemo-resistance via ZNRF2.11
272446712016The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids.11
272446712016The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids.11
227979232012ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.11
227979232012ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.11
145618662003ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases.25
145618662003ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases.25

Citation

Dessen P

ZNRF2 (zinc and ring finger 2)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57532/znrf2-(zinc-and-ring-finger-2)