EIF5 (eukaryotic translation initiation factor 5)

2018-07-01  

Identity

HGNC
LOCATION
14q32.32
LOCUSID
ALIAS
EIF-5,EIF-5A
FUSION GENES

Other Information

Locus ID:

NCBI: 1983
MIM: 601710
HGNC: 3299
Ensembl: ENSG00000100664

Variants:

dbSNP: 1983
ClinVar: 1983
TCGA: ENSG00000100664
COSMIC: EIF5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100664ENST00000216554P55010
ENSG00000100664ENST00000216554A0A024R6Q1
ENSG00000100664ENST00000392715P55010
ENSG00000100664ENST00000392715A0A024R6Q1
ENSG00000100664ENST00000558265H0YN40
ENSG00000100664ENST00000558316H0YLZ1
ENSG00000100664ENST00000558506P55010
ENSG00000100664ENST00000558506A0A024R6Q1
ENSG00000100664ENST00000559130H0YK11
ENSG00000100664ENST00000559532H0YM54
ENSG00000100664ENST00000560338H0YMJ8
ENSG00000100664ENST00000560763H0YK29
ENSG00000100664ENST00000561325H0YM54

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232930292013Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex.38
228137442012The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β.35
165841902006Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors.24
162274382005CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression.20
243199942013The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.17
167817362006The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5.16
267179812016Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysis.12
273257402016Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation.10
289817282017Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide.9
279867512017A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer.6

Citation

Dessen P

EIF5 (eukaryotic translation initiation factor 5)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57535/eif5-(eukaryotic-translation-initiation-factor-5)