DCTPP1 (dCTP pyrophosphatase 1)

2018-07-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
CDA03,RS21C6,XTP3TPA

Other Information

Locus ID:

NCBI: 79077
MIM: 615840
HGNC: 28777
Ensembl: ENSG00000179958

Variants:

dbSNP: 79077
ClinVar: 79077
TCGA: ENSG00000179958
COSMIC: DCTPP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179958ENST00000319285Q9H773
ENSG00000179958ENST00000565758H3BPN2
ENSG00000179958ENST00000567983H3BSA6
ENSG00000179958ENST00000568434H3BPN2
ENSG00000179958ENST00000568973H3BPN2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
216713272011Triptolide directly inhibits dCTP pyrophosphatase.20
244673962014The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells.14
276124272016DCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically.4
298745562018Autophagy induced by overexpression of DCTPP1 promotes tumor progression and predicts poor clinical outcome in prostate cancer.1
313778452020DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools.0

Citation

Dessen P

DCTPP1 (dCTP pyrophosphatase 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57536/dctpp1-(dctp-pyrophosphatase-1)