SETDB2 (SET domain bifurcated histone lysine methyltransferase 2)

2018-07-01  

Identity

HGNC
LOCATION
13q14.2
LOCUSID
ALIAS
C13orf4,CLLD8,CLLL8,KMT1F
FUSION GENES

Other Information

Locus ID:

NCBI: 83852
MIM: 607865
HGNC: 20263
Ensembl: ENSG00000136169

Variants:

dbSNP: 83852
ClinVar: 83852
TCGA: ENSG00000136169
COSMIC: SETDB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136169ENST00000258672X6R383
ENSG00000136169ENST00000317257Q96T68
ENSG00000136169ENST00000354234Q96T68
ENSG00000136169ENST00000611815A0A087WYZ9

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381595742024Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46.0
381595742024Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46.0
365043532023Histone lysine methyltransferase SETDB2 suppresses NRF2 to restrict tumor progression and modulates chemotherapy sensitivity in lung adenocarcinoma.3
365043532023Histone lysine methyltransferase SETDB2 suppresses NRF2 to restrict tumor progression and modulates chemotherapy sensitivity in lung adenocarcinoma.3
344799912021Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2.16
344799912021Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2.16
308500152019Emerging roles of H3K9me3, SETDB1 and SETDB2 in therapy-induced cellular reprogramming.35
313501762019The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair.49
308500152019Emerging roles of H3K9me3, SETDB1 and SETDB2 in therapy-induced cellular reprogramming.35
313501762019The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair.49
292341672018The SETDB2 locus: evidence for a genetic link between handedness and atopic disease.4
296948932018SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression.13
292341672018The SETDB2 locus: evidence for a genetic link between handedness and atopic disease.4
296948932018SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression.13
290992762017SETDB2 and RIOX2 are differentially expressed among renal cell tumor subtypes, associating with prognosis and metastization.14

Citation

Dessen P

SETDB2 (SET domain bifurcated histone lysine methyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57538/favicon/humanGenome