RNGTT (RNA guanylyltransferase and 5-phosphatase)

2018-07-01  

Identity

HGNC
RNGTT
LOCATION
6q15
LOCUSID
8732
ALIAS
CAP1A,HCE,HCE1,hCAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8732
MIM: 603512
HGNC: 10073
Ensembl: ENSG00000111880

Variants:

dbSNP: 8732
ClinVar: 8732
TCGA: ENSG00000111880
COSMIC: RNGTT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111880ENST00000369475O60942
ENSG00000111880ENST00000369485O60942
ENSG00000111880ENST00000538899O60942

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
RNA Pol II CTD phosphorylation and interaction with CE during HIV infectionREACTOMER-HSA-167160
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Pol II CTD phosphorylation and interaction with CEREACTOMER-HSA-77075
mRNA CappingREACTOMER-HSA-72086

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
277568912016c-Myc deregulation induces mRNA capping enzyme dependency.11
277568912016c-Myc deregulation induces mRNA capping enzyme dependency.11
251371422014The cytoplasmic capping complex assembles on adapter protein nck1 bound to the proline-rich C-terminus of Mammalian capping enzyme.21
251371422014The cytoplasmic capping complex assembles on adapter protein nck1 bound to the proline-rich C-terminus of Mammalian capping enzyme.21
233499422013The immunosuppressive agent mizoribine monophosphate is an inhibitor of the human RNA capping enzyme.3
233499422013The immunosuppressive agent mizoribine monophosphate is an inhibitor of the human RNA capping enzyme.3
216367842011Structure of the guanylyltransferase domain of human mRNA capping enzyme.27
216367842011Structure of the guanylyltransferase domain of human mRNA capping enzyme.27
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

RNGTT (RNA guanylyltransferase and 5-phosphatase)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57550/rngtt-(rna-guanylyltransferase-and-5-phosphatase)