Identity
HGNC
LOCATION
7p13
LOCUSID
ALIAS
AKGDH,E1k,KGD1,OGDC,OGDH2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4967
MIM: 613022
HGNC: 8124
Ensembl: ENSG00000105953
Variants:
dbSNP: 4967
ClinVar: 4967
TCGA: ENSG00000105953
COSMIC: OGDH
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA451846 | valproic acid | Chemical | Pathway | associated | 23407051 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38483541 | 2024 | OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma. | 0 |
| 38483541 | 2024 | OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma. | 0 |
| 36520152 | 2023 | Biallelic variants in OGDH encoding oxoglutarate dehydrogenase lead to a neurodevelopmental disorder characterized by global developmental delay, movement disorder, and metabolic abnormalities. | 6 |
| 36520152 | 2023 | Biallelic variants in OGDH encoding oxoglutarate dehydrogenase lead to a neurodevelopmental disorder characterized by global developmental delay, movement disorder, and metabolic abnormalities. | 6 |
| 32383294 | 2021 | A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease. | 15 |
| 32383294 | 2021 | A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease. | 15 |
| 32024885 | 2020 | Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues. | 17 |
| 32160276 | 2020 | DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo. | 16 |
| 32024885 | 2020 | Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues. | 17 |
| 32160276 | 2020 | DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo. | 16 |
| 31247190 | 2019 | OGDH mediates the inhibition of SIRT5 on cell proliferation and migration of gastric cancer. | 18 |
| 31247190 | 2019 | OGDH mediates the inhibition of SIRT5 on cell proliferation and migration of gastric cancer. | 18 |
| 28396387 | 2017 | PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. | 24 |
| 28396387 | 2017 | PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. | 24 |
| 26936970 | 2016 | Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression. | 11 |
Citation
Dessen P
OGDH (oxoglutarate dehydrogenase)
Atlas Genet Cytogenet Oncol Haematol. 2018-07-01
Online version: http://atlasgeneticsoncology.org/gene/57555/
