ADAMTS8 (ADAM metallopeptidase with thrombospondin type 1 motif 8)

2003-02-01  

Identity

HGNC
LOCATION
11q24.3
LOCUSID
ALIAS
ADAM-TS8,METH2

Other Information

Locus ID:

NCBI: 11095
MIM: 605175
HGNC: 224
Ensembl: ENSG00000134917

Variants:

dbSNP: 11095
ClinVar: 11095
TCGA: ENSG00000134917
COSMIC: ADAMTS8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134917ENST00000257359Q9UP79

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-glycosylation of TSR domain-containing proteinsREACTOMER-HSA-5173214
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective B3GALTL causes Peters-plus syndrome (PpS)REACTOMER-HSA-5083635

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
152969362004ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage.41
176062622008ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.34
165700502006Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours.29
161526182006ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma.27
153285192004METH-2 silencing and promoter hypermethylation in NSCLC.17
241845402014The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK-ERK signaling and is silenced in carcinomas by CpG methylation.17
274939582016Downregulation of ADAMTS8 by DNA Hypermethylation in Gastric Cancer and Its Clinical Significance.5
288140852017Differentially regulated ADAMTS1, 8, and 18 in gastric adenocarcinoma.3
243844272014Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease.2

Citation

Dessen P

ADAMTS8 (ADAM metallopeptidase with thrombospondin type 1 motif 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/576/adamts8-(adam-metallopeptidase-with-thrombospondin-type-1-motif-8)