DCAF11 (DDB1 and CUL4 associated factor 11)

2018-11-01  

Identity

HGNC
LOCATION
14q12
LOCUSID
ALIAS
GL014,PRO2389,WDR23

Other Information

Locus ID:

NCBI: 80344
MIM: 613317
HGNC: 20258
Ensembl: ENSG00000100897

Variants:

dbSNP: 80344
ClinVar: 80344
TCGA: ENSG00000100897
COSMIC: DCAF11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100897ENST00000326009H0YN03
ENSG00000100897ENST00000396936Q8TEB1
ENSG00000100897ENST00000396941Q8TEB1
ENSG00000100897ENST00000446197Q8TEB1
ENSG00000100897ENST00000557802H0YN03
ENSG00000100897ENST00000557810H0YL64
ENSG00000100897ENST00000557888H0YN03
ENSG00000100897ENST00000558215H0YNK2
ENSG00000100897ENST00000558408H0YMZ4
ENSG00000100897ENST00000558638H0YM86
ENSG00000100897ENST00000558706H0YLF1
ENSG00000100897ENST00000558914H0YL29
ENSG00000100897ENST00000559017H0YM56
ENSG00000100897ENST00000559115Q8TEB1
ENSG00000100897ENST00000559144H0YL98
ENSG00000100897ENST00000559288H0YNT0
ENSG00000100897ENST00000559354H0YN21
ENSG00000100897ENST00000559382H0YMF7
ENSG00000100897ENST00000559396H0YLQ1
ENSG00000100897ENST00000559451H0YLF1
ENSG00000100897ENST00000559593H0YKR8
ENSG00000100897ENST00000559796H0YLX7
ENSG00000100897ENST00000560457H0YN03
ENSG00000100897ENST00000560459H0YN15
ENSG00000100897ENST00000560614H0YLF1
ENSG00000100897ENST00000560713H0YLH4
ENSG00000100897ENST00000560901H0YLB2
ENSG00000100897ENST00000561001H0YMN6
ENSG00000100897ENST00000561041H0YNS2
ENSG00000100897ENST00000561375H0YN92

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
337832072021DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras.46
337832072021DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras.46
328390902020WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes.4
328390902020WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes.4
315861122019TFEB activates Nrf2 by repressing its E3 ubiquitin ligase DCAF11 and promoting phosphorylation of p62.21
315861122019TFEB activates Nrf2 by repressing its E3 ubiquitin ligase DCAF11 and promoting phosphorylation of p62.21
293776002018Activation of TNF-α/NF-κB axis enhances CRL4B(DCAF)(11) E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells.21
293776002018Activation of TNF-α/NF-κB axis enhances CRL4B(DCAF)(11) E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells.21
284467512017CRL4B(DCAF11) E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cells.25
284535202017WDR23 regulates NRF2 independently of KEAP1.47
284467512017CRL4B(DCAF11) E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cells.25
284535202017WDR23 regulates NRF2 independently of KEAP1.47
272031822016CRL4(WDR23)-Mediated SLBP Ubiquitylation Ensures Histone Supply during DNA Replication.21
272548192016DDB1 and CUL4 associated factor 11 (DCAF11) mediates degradation of Stem-loop binding protein at the end of S phase.14
272031822016CRL4(WDR23)-Mediated SLBP Ubiquitylation Ensures Histone Supply during DNA Replication.21

Citation

Dessen P

DCAF11 (DDB1 and CUL4 associated factor 11)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57607/dcaf11-(ddb1-and-cul4-associated-factor-11)