HNF4G (hepatocyte nuclear factor 4 gamma)

2018-11-01  

Identity

HGNC
LOCATION
8q21.13
LOCUSID
ALIAS
NR2A2,NR2A3
FUSION GENES

Other Information

Locus ID:

NCBI: 3174
MIM: 605966
HGNC: 5026
Ensembl: ENSG00000164749

Variants:

dbSNP: 3174
ClinVar: 3174
TCGA: ENSG00000164749
COSMIC: HNF4G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164749ENST00000354370Q14541
ENSG00000164749ENST00000396423Q14541
ENSG00000164749ENST00000674002F1D8Q4

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Maturity onset diabetes of the youngKEGGko04950
Maturity onset diabetes of the youngKEGGhsa04950
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280
Developmental BiologyREACTOMER-HSA-1266738
Regulation of beta-cell developmentREACTOMER-HSA-186712
Regulation of gene expression in beta cellsREACTOMER-HSA-210745

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
366075912023HNF4G stimulates the development of pancreatic cancer by promoting IGF2BP2 transcription.3
366075912023HNF4G stimulates the development of pancreatic cancer by promoting IGF2BP2 transcription.3
349653882022Hepatocyte nuclear factor 4 gamma (HNF4G) is correlated with poor prognosis and promotes tumor cell growth by inhibiting caspase-dependent intrinsic apoptosis in colorectal cancer.2
349653882022Hepatocyte nuclear factor 4 gamma (HNF4G) is correlated with poor prognosis and promotes tumor cell growth by inhibiting caspase-dependent intrinsic apoptosis in colorectal cancer.2
327378642021Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation.33
337589322021microRNA-320b suppresses HNF4G and IGF2BP2 expression to inhibit angiogenesis and tumor growth of lung cancer.25
347942182021[Expression of hepatocyte nuclear factor 4γ in gastric carcinoma and its role in cell proliferation and stemness].0
327378642021Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation.33
337589322021microRNA-320b suppresses HNF4G and IGF2BP2 expression to inhibit angiogenesis and tumor growth of lung cancer.25
347942182021[Expression of hepatocyte nuclear factor 4γ in gastric carcinoma and its role in cell proliferation and stemness].0
302245202018Induction of Hepatic Metabolic Functions by a Novel Variant of Hepatocyte Nuclear Factor 4γ.7
302245202018Induction of Hepatic Metabolic Functions by a Novel Variant of Hepatocyte Nuclear Factor 4γ.7
284604742017TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men.7
284604742017TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men.7
235636072013Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.323

Citation

Dessen P

HNF4G (hepatocyte nuclear factor 4 gamma)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57649/hnf4g-(hepatocyte-nuclear-factor-4-gamma)