Identity
HGNC
LOCATION
3q29
LOCUSID
ALIAS
ELLP3030,GARPL1,LRRC33,SENEBAC,UNQ3030
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 375387
MIM: 615322
HGNC: 24613
Ensembl: ENSG00000174004
Variants:
dbSNP: 375387
ClinVar: 375387
TCGA: ENSG00000174004
COSMIC: NRROS
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000174004 | ENST00000328557 | Q86YC3 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36008481 | 2022 | Specificity of TGF-β1 signal designated by LRRC33 and integrin α(V)β(8). | 6 |
| 36008481 | 2022 | Specificity of TGF-β1 signal designated by LRRC33 and integrin α(V)β(8). | 6 |
| 32100099 | 2020 | Biallelic mutations in NRROS cause an early onset lethal microgliopathy. | 12 |
| 32197075 | 2020 | Bi-allelic LoF NRROS Variants Impairing Active TGF-β1 Delivery Cause a Severe Infantile-Onset Neurodegenerative Condition with Intracranial Calcification. | 12 |
| 32100099 | 2020 | Biallelic mutations in NRROS cause an early onset lethal microgliopathy. | 12 |
| 32197075 | 2020 | Bi-allelic LoF NRROS Variants Impairing Active TGF-β1 Delivery Cause a Severe Infantile-Onset Neurodegenerative Condition with Intracranial Calcification. | 12 |
| 31600200 | 2019 | LRRC33 is a novel binding and potential regulating protein of TGF-β1 function in human acute myeloid leukemia cells. | 14 |
| 31644309 | 2019 | Association Study Reveals One Susceptibility Locus with Vitiligo in the Chinese Han Population. | 4 |
| 31600200 | 2019 | LRRC33 is a novel binding and potential regulating protein of TGF-β1 function in human acute myeloid leukemia cells. | 14 |
| 31644309 | 2019 | Association Study Reveals One Susceptibility Locus with Vitiligo in the Chinese Han Population. | 4 |
| 24550525 | 2014 | Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors. | 7 |
| 24550525 | 2014 | Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors. | 7 |
| 23545260 | 2013 | Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-κB activation. | 14 |
| 23545260 | 2013 | Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-κB activation. | 14 |
Citation
Dessen P
NRROS (negative regulator of reactive oxygen species)
Atlas Genet Cytogenet Oncol Haematol. 2018-11-01
Online version: http://atlasgeneticsoncology.org/gene/57651/nrros-(negative-regulator-of-reactive-oxygen-species)
