CFAP410 (cilia and flagella associated protein 410)

2018-11-01  

Identity

HGNC
LOCATION
21q22.3
LOCUSID
ALIAS
C21orf2,LRRC76,RDMS,SMDAX,YF5/A2

Other Information

Locus ID:

NCBI: 755
MIM: 603191
HGNC: 1260
Ensembl: ENSG00000160226

Variants:

dbSNP: 755
ClinVar: 755
TCGA: ENSG00000160226
COSMIC: CFAP410

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160226ENST00000325223O43822
ENSG00000160226ENST00000339818O43822
ENSG00000160226ENST00000397956O43822

References

Pubmed IDYearTitleCitations
371884792023Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases.2
371884792023Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases.2
284223942017Homozygous variant in C21orf2 in a case of Jeune syndrome with severe thoracic involvement: Extending the phenotypic spectrum.12
284223942017Homozygous variant in C21orf2 in a case of Jeune syndrome with severe thoracic involvement: Extending the phenotypic spectrum.12
269744332016Axial Spondylometaphyseal Dysplasia Is Caused by C21orf2 Mutations.18
274553482016Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.274
275488992016Identification of Novel Mutations in the LRR-Cap Domain of C21orf2 in Japanese Patients With Retinitis Pigmentosa and Cone-Rod Dystrophy.12
269744332016Axial Spondylometaphyseal Dysplasia Is Caused by C21orf2 Mutations.18
274553482016Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.274
275488992016Identification of Novel Mutations in the LRR-Cap Domain of C21orf2 in Japanese Patients With Retinitis Pigmentosa and Cone-Rod Dystrophy.12
262904902015The NEK1 interactor, C21ORF2, is required for efficient DNA damage repair.36
262941032015C21orf2 is mutated in recessive early-onset retinal dystrophy with macular staphyloma and encodes a protein that localises to the photoreceptor primary cilium.14
262904902015The NEK1 interactor, C21ORF2, is required for efficient DNA damage repair.36
262941032015C21orf2 is mutated in recessive early-onset retinal dystrophy with macular staphyloma and encodes a protein that localises to the photoreceptor primary cilium.14
150682442003Reduction of chromatin assembly factor 1 p60 and C21orf2 protein, encoded on chromosome 21, in Down syndrome brain.9

Citation

Dessen P

CFAP410 (cilia and flagella associated protein 410)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57670/cfap410-(cilia-and-flagella-associated-protein-410)