FUT9 (fucosyltransferase 9)

2018-11-01  

Identity

HGNC
LOCATION
6q16.1
LOCUSID
ALIAS
Fuc-TIX
FUSION GENES

Other Information

Locus ID:

NCBI: 10690
MIM: 606865
HGNC: 4020
Ensembl: ENSG00000172461

Variants:

dbSNP: 10690
ClinVar: 10690
TCGA: ENSG00000172461
COSMIC: FUT9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172461ENST00000302103Q9Y231

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Glycosphingolipid biosynthesis - globo and isoglobo seriesKEGGhsa00603
Metabolic pathwaysKEGGhsa01100
Mannose type O-glycan biosynthesisKEGGko00515
Mannose type O-glycan biosynthesisKEGGhsa00515

References

Pubmed IDYearTitleCitations
376743632024ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9.0
376743632024ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9.0
291965082017An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer.26
291965082017An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer.26
231923502013Silencing α1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion.63
232631992013N-glycosylations of human α1,3-fucosyltransferase IX are required for full enzyme activity.1
231923502013Silencing α1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion.63
232631992013N-glycosylations of human α1,3-fucosyltransferase IX are required for full enzyme activity.1
230005742012Expression of glycogenes in differentiating human NT2N neurons. Downregulation of fucosyltransferase 9 leads to decreased Lewis(x) levels and impaired neurite outgrowth.15
230005742012Expression of glycogenes in differentiating human NT2N neurons. Downregulation of fucosyltransferase 9 leads to decreased Lewis(x) levels and impaired neurite outgrowth.15
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
194608852009A variant in the gene FUT9 is associated with susceptibility to placental malaria infection.5
194608852009A variant in the gene FUT9 is associated with susceptibility to placental malaria infection.5
183950132008Human fucosyltransferase IX: specificity towards N-linked glycoproteins and relevance of the cytoplasmic domain in intra-Golgi localization.8

Citation

Dessen P

FUT9 (fucosyltransferase 9)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57705/