GGT2 (gamma-glutamyltransferase 2)

2018-11-01  

Identity

HGNC
GGT2
LOCATION
22q11.21
LOCUSID
728441
ALIAS
GGT,GGT

Other Information

Locus ID:

NCBI: 728441
MIM: 137181
HGNC: 4251
Ensembl: ENSG00000133475

Variants:

dbSNP: 728441
ClinVar: 728441
TCGA: ENSG00000133475
COSMIC: GGT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133475ENST00000401924P36268
ENSG00000133475ENST00000405188B5MCK8

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)REACTOMER-HSA-2142691
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Glutathione synthesis and recyclingREACTOMER-HSA-174403
Aflatoxin activation and detoxificationREACTOMER-HSA-5423646

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379044802023Clinical application value of hepatitis B virus basal core promoter 1762/1764 and GGTII and GGT in patients with HBV-DNA-positive primary liver cancer.0
379044802023Clinical application value of hepatitis B virus basal core promoter 1762/1764 and GGTII and GGT in patients with HBV-DNA-positive primary liver cancer.0
251804442015Gamma glutamyl transferase activity is independently associated with oxidative stress rather than SYNTAX score.9
251804442015Gamma glutamyl transferase activity is independently associated with oxidative stress rather than SYNTAX score.9
252808032014Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study.16
252808032014Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study.16
227495592013High-sensitivity γ-glutamyltransferase fraction pattern in alcohol addicts and abstainers.7
236827722013Human GGT2 does not autocleave into a functional enzyme: A cautionary tale for interpretation of microarray data on redox signaling.11
227495592013High-sensitivity γ-glutamyltransferase fraction pattern in alcohol addicts and abstainers.7
236827722013Human GGT2 does not autocleave into a functional enzyme: A cautionary tale for interpretation of microarray data on redox signaling.11
219861032012Association between γ-glutamyltransferase, adiponectin and arterial stiffness.9
222693852012K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2.14
231380052012Serum gamma-glutamyltransferase as a risk factor for general cardiovascular disease prediction in Koreans.2
219861032012Association between γ-glutamyltransferase, adiponectin and arterial stiffness.9
222693852012K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2.14

Citation

Dessen P

GGT2 (gamma-glutamyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57716/ggt2-(gamma-glutamyltransferase-2)