Identity
HGNC
LOCATION
4q24
LOCUSID
ALIAS
BIGM103,CDG2N,LZT-Hs6,PP3105,ZIP8
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 64116
MIM: 608732
HGNC: 20862
Ensembl: ENSG00000138821
Variants:
dbSNP: 64116
ClinVar: 64116
TCGA: ENSG00000138821
COSMIC: SLC39A8
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443309 | Alcoholism | Disease | ClinicalAnnotation | associated | PD | 32451486 | |
| PA448073 | ethanol | Chemical | ClinicalAnnotation | associated | PD | 32451486 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38103342 | 2024 | Identification of ZIP8-induced ferroptosis as a major type of cell death in monocytes under sepsis conditions. | 1 |
| 38309537 | 2024 | Targeting ZIP8 mediated ferroptosis as a novel strategy to protect against the retinal pigment epithelial degeneration. | 2 |
| 38103342 | 2024 | Identification of ZIP8-induced ferroptosis as a major type of cell death in monocytes under sepsis conditions. | 1 |
| 38309537 | 2024 | Targeting ZIP8 mediated ferroptosis as a novel strategy to protect against the retinal pigment epithelial degeneration. | 2 |
| 34924116 | 2022 | Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP. | 13 |
| 35636252 | 2022 | Effects of individual amino acid mutations of zinc transporter ZIP8 on manganese- and cadmium-transporting activity. | 5 |
| 35642632 | 2022 | Deficiency in the zinc transporter ZIP8 impairs epithelia renewal and enhances lung fibrosis. | 1 |
| 35787370 | 2022 | Calcium and the Ca-ATPase SPCA1 modulate plasma membrane abundance of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain microvascular endothelial cells. | 6 |
| 34924116 | 2022 | Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP. | 13 |
| 35636252 | 2022 | Effects of individual amino acid mutations of zinc transporter ZIP8 on manganese- and cadmium-transporting activity. | 5 |
| 35642632 | 2022 | Deficiency in the zinc transporter ZIP8 impairs epithelia renewal and enhances lung fibrosis. | 1 |
| 35787370 | 2022 | Calcium and the Ca-ATPase SPCA1 modulate plasma membrane abundance of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain microvascular endothelial cells. | 6 |
| 33608496 | 2021 | Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling. | 10 |
| 33795795 | 2021 | ZIP8 exacerbates collagen-induced arthritis by increasing pathogenic T cell responses. | 1 |
| 34198528 | 2021 | HIF-1α Dependent Upregulation of ZIP8, ZIP14, and TRPA1 Modify Intracellular Zn(2+) Accumulation in Inflammatory Synoviocytes. | 8 |
Citation
Dessen P
SLC39A8 (solute carrier family 39 member 8)
Atlas Genet Cytogenet Oncol Haematol. 2018-11-01
Online version: http://atlasgeneticsoncology.org/gene/57734/slc39a8-(solute-carrier-family-39-member-8)
