ALG3 (ALG3 alpha-1,3- mannosyltransferase)

2018-11-01  

Identity

HGNC
LOCATION
3q27.1
LOCUSID
ALIAS
CDG1D,CDGS4,CDGS6,D16Ertd36e,NOT56L,Not56,not
FUSION GENES

Other Information

Locus ID:

NCBI: 10195
MIM: 608750
HGNC: 23056
Ensembl: ENSG00000214160

Variants:

dbSNP: 10195
ClinVar: 10195
TCGA: ENSG00000214160
COSMIC: ALG3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000214160ENST00000397676Q92685
ENSG00000214160ENST00000411922F8WE30
ENSG00000214160ENST00000414845H7BZZ2
ENSG00000214160ENST00000423996F8WF93
ENSG00000214160ENST00000445626Q92685
ENSG00000214160ENST00000446569H7C0X4
ENSG00000214160ENST00000455059C9J7S5

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
N-glycan precursor biosynthesisKEGGhsa_M00055
N-glycan precursor biosynthesisKEGGM00055
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383294242024Comprehensive analysis of ALG3 in pan-cancer and validation of ALG3 as an onco-immunological biomarker in breast cancer.0
383294242024Comprehensive analysis of ALG3 in pan-cancer and validation of ALG3 as an onco-immunological biomarker in breast cancer.0
351816252022ALG3 Is a Potential Biomarker for the Prognosis of Bladder Cancer.0
356765642022Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy.13
359801172022CircPTK2 promotes cell viability, cell cycle process, and glycolysis and inhibits cell apoptosis in acute myeloid leukemia by regulating miR-582-3p/ALG3 axis.1
362311022022ALG3 Promotes Peritoneal Metastasis of Ovarian Cancer through Increasing Interaction of α1,3-mannosylated uPAR and ADAM8.4
351816252022ALG3 Is a Potential Biomarker for the Prognosis of Bladder Cancer.0
356765642022Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy.13
359801172022CircPTK2 promotes cell viability, cell cycle process, and glycolysis and inhibits cell apoptosis in acute myeloid leukemia by regulating miR-582-3p/ALG3 axis.1
362311022022ALG3 Promotes Peritoneal Metastasis of Ovarian Cancer through Increasing Interaction of α1,3-mannosylated uPAR and ADAM8.4
330841112021ALG3 contributes to the malignant properties of OSCC cells by regulating CDK-Cyclin pathway.7
339310752021ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer.33
330841112021ALG3 contributes to the malignant properties of OSCC cells by regulating CDK-Cyclin pathway.7
339310752021ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer.33
318990492020ALG3 contributes to the malignancy of non-small cell lung cancer and is negatively regulated by MiR-98-5p.22

Citation

Dessen P

ALG3 (ALG3 alpha-1,3- mannosyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57758/alg3-(alg3-alpha-1-3-mannosyltransferase)