NUP43 (nucleoporin 43)

2018-11-01 Affiliation

Identity

HGNC

NUP43

LOCATION

6q25.1

LOCUSID

348995

ALIAS

bA350J20.1,p42

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 348995
MIM: 608141
HGNC: 21182
Ensembl: ENSG00000120253

Variants:

dbSNP: 348995
ClinVar: 348995
TCGA: ENSG00000120253
COSMIC: NUP43

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000120253	ENST00000340413	Q8NFH3
ENSG00000120253	ENST00000367402	B4DVD1
ENSG00000120253	ENST00000367404	Q8NFH3
ENSG00000120253	ENST00000403890	B4E301
ENSG00000120253	ENST00000543637	F5H0E3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RNA transport	KEGG	ko03013
RNA transport	KEGG	hsa03013
Nuclear pore complex	KEGG	hsa_M00427
Nuclear pore complex	KEGG	M00427
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
SUMOylation	REACTOME	R-HSA-2990846
SUMO E3 ligases SUMOylate target proteins	REACTOME	R-HSA-3108232
SUMOylation of DNA damage response and repair proteins	REACTOME	R-HSA-3108214
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Rev-mediated nuclear export of HIV RNA	REACTOME	R-HSA-165054
Host Interactions of HIV factors	REACTOME	R-HSA-162909
Interactions of Vpr with host cellular proteins	REACTOME	R-HSA-176033
Vpr-mediated nuclear import of PICs	REACTOME	R-HSA-180910
Interactions of Rev with host cellular proteins	REACTOME	R-HSA-177243
Nuclear import of Rev protein	REACTOME	R-HSA-180746
Influenza Infection	REACTOME	R-HSA-168254
Influenza Life Cycle	REACTOME	R-HSA-168255
Transport of Ribonucleoproteins into the Host Nucleus	REACTOME	R-HSA-168271
Influenza Viral RNA Transcription and Replication	REACTOME	R-HSA-168273
Viral Messenger RNA Synthesis	REACTOME	R-HSA-168325
Export of Viral Ribonucleoproteins from Nucleus	REACTOME	R-HSA-168274
NEP/NS2 Interacts with the Cellular Export Machinery	REACTOME	R-HSA-168333
Host Interactions with Influenza Factors	REACTOME	R-HSA-168253
NS1 Mediated Effects on Host Pathways	REACTOME	R-HSA-168276
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Antiviral mechanism by IFN-stimulated genes	REACTOME	R-HSA-1169410
ISG15 antiviral mechanism	REACTOME	R-HSA-1169408
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases Activate Formins	REACTOME	R-HSA-5663220
Gene Expression	REACTOME	R-HSA-74160
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
Transport of Mature Transcript to Cytoplasm	REACTOME	R-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing Transcript	REACTOME	R-HSA-159236
Transport of Mature mRNAs Derived from Intronless Transcripts	REACTOME	R-HSA-159234
Transport of the SLBP Dependant Mature mRNA	REACTOME	R-HSA-159230
Transport of the SLBP independent Mature mRNA	REACTOME	R-HSA-159227
Transport of Mature mRNA Derived from an Intronless Transcript	REACTOME	R-HSA-159231
Gene Silencing by RNA	REACTOME	R-HSA-211000
Transcriptional regulation by small RNAs	REACTOME	R-HSA-5578749
Metabolism of non-coding RNA	REACTOME	R-HSA-194441
snRNP Assembly	REACTOME	R-HSA-191859
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Nuclear Envelope Breakdown	REACTOME	R-HSA-2980766
Nuclear Pore Complex (NPC) Disassembly	REACTOME	R-HSA-3301854
Mitotic Prometaphase	REACTOME	R-HSA-68877
Resolution of Sister Chromatid Cohesion	REACTOME	R-HSA-2500257
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Anaphase	REACTOME	R-HSA-68882
Separation of Sister Chromatids	REACTOME	R-HSA-2467813
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Hexose transport	REACTOME	R-HSA-189200
Glucose transport	REACTOME	R-HSA-70153
Regulation of Glucokinase by Glucokinase Regulatory Protein	REACTOME	R-HSA-170822
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to heat stress	REACTOME	R-HSA-3371556
Regulation of HSF1-mediated heat shock response	REACTOME	R-HSA-3371453
tRNA processing	REACTOME	R-HSA-72306
tRNA processing in the nucleus	REACTOME	R-HSA-6784531
SUMOylation of RNA binding proteins	REACTOME	R-HSA-4570464
SUMOylation of DNA replication proteins	REACTOME	R-HSA-4615885

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
29402145	2018	High NUP43 expression might independently predict poor overall survival in luminal A and in HER2+ breast cancer.	14
29402145	2018	High NUP43 expression might independently predict poor overall survival in luminal A and in HER2+ breast cancer.	14
26391640	2015	Crystal structure of human nuclear pore complex component NUP43.	12
26391640	2015	Crystal structure of human nuclear pore complex component NUP43.	12

Citation

Dessen P

NUP43 (nucleoporin 43)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57760/nup43-(nucleoporin-43)

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