ZC3HAV1 (zinc finger CCCH-type containing, antiviral 1)

2018-12-01  

Identity

HGNC
LOCATION
7q34
LOCUSID
ALIAS
ARTD13,FLB6421,PARP13,ZAP,ZC3H2,ZC3HDC2
FUSION GENES

Other Information

Locus ID:

NCBI: 56829
MIM: 607312
HGNC: 23721
Ensembl: ENSG00000105939

Variants:

dbSNP: 56829
ClinVar: 56829
TCGA: ENSG00000105939
COSMIC: ZC3HAV1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105939ENST00000242351Q7Z2W4
ENSG00000105939ENST00000460845H7C5K1
ENSG00000105939ENST00000464606C9J6P4
ENSG00000105939ENST00000471652Q7Z2W4

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
218761792011Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation.85
182259582008Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein.70
211024352011ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses.69
238536012013Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein.69
260011152015The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition.44
237762192013Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform.36
179283532007The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses.35
200481472010Viral induction of the zinc finger antiviral protein is IRF3-dependent but NF-kappaB-independent.32
266259842015Herpes simplex virus 1 UL41 protein abrogates the antiviral activity of hZAP by degrading its mRNA.26
253823122014PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 transcript.25

Citation

Dessen P

ZC3HAV1 (zinc finger CCCH-type containing, antiviral 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-12-01

Online version: http://atlasgeneticsoncology.org/gene/57769/zc3hav1-(zinc-finger-ccch-type-containing-antiviral-1)