EXOG (exo/endonuclease G)

2018-12-01  

Identity

HGNC
LOCATION
3p22.2
LOCUSID
ALIAS
ENDOGL1,ENDOGL2,ENGL,ENGL-a,ENGL-b,ENGLA,ENGLB

Other Information

Locus ID:

NCBI: 9941
MIM: 604051
HGNC: 3347
Ensembl: ENSG00000157036

Variants:

dbSNP: 9941
ClinVar: 9941
TCGA: ENSG00000157036
COSMIC: EXOG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157036ENST00000287675Q9Y2C4
ENSG00000157036ENST00000412107F2Z2D3
ENSG00000157036ENST00000422077Q9Y2C4
ENSG00000157036ENST00000431472F8WE28
ENSG00000157036ENST00000436414F8WEP0
ENSG00000157036ENST00000438992F2Z2D3
ENSG00000157036ENST00000443942F2Z2D3
ENSG00000157036ENST00000447573F2Z2D3
ENSG00000157036ENST00000450732H7C451
ENSG00000157036ENST00000453767H7C0W6
ENSG00000157036ENST00000454803F8WC11
ENSG00000157036ENST00000457367F8WE38
ENSG00000157036ENST00000470291H0Y8P1
ENSG00000157036ENST00000630638F2Z2D3

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
358191942022In vitro reconstitution reveals a key role of human mitochondrial EXOG in RNA primer processing.2
365164392022Human EXOG Possesses Strong AP Hydrolysis Activity: Implication on Mitochondrial DNA Base Excision Repair.3
358191942022In vitro reconstitution reveals a key role of human mitochondrial EXOG in RNA primer processing.2
365164392022Human EXOG Possesses Strong AP Hydrolysis Activity: Implication on Mitochondrial DNA Base Excision Repair.3
309497022019A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.10
309497022019A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.10
284668552017A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.14
284668552017A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.14
239865852013Mitochondrial nucleases ENDOG and EXOG participate in mitochondrial DNA depletion initiated by herpes simplex virus 1 UL12.5.20
239865852013Mitochondrial nucleases ENDOG and EXOG participate in mitochondrial DNA depletion initiated by herpes simplex virus 1 UL12.5.20
217686462011Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair.79
217686462011Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair.79
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
181875032008EXOG, a novel paralog of Endonuclease G in higher eukaryotes.41

Citation

Dessen P

EXOG (exo/endonuclease G)

Atlas Genet Cytogenet Oncol Haematol. 2018-12-01

Online version: http://atlasgeneticsoncology.org/gene/57775/exog-(exo-endonuclease-g)