VNN2 (vanin 2)

2018-12-01 Affiliation

Identity

HGNC

VNN2

LOCATION

6q23.2

LOCUSID

8875

ALIAS

FOAP-4,GPI-80

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8875
MIM: 603571
HGNC: 12706
Ensembl: ENSG00000112303

Variants:

dbSNP: 8875
ClinVar: 8875
TCGA: ENSG00000112303
COSMIC: VNN2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000112303	ENST00000326499	O95498
ENSG00000112303	ENST00000392389	J3QT03
ENSG00000112303	ENST00000418593	J3KQ55
ENSG00000112303	ENST00000422400	J3KQQ7
ENSG00000112303	ENST00000524919	E9PL76
ENSG00000112303	ENST00000525270	O95498
ENSG00000112303	ENST00000525289	O95498
ENSG00000112303	ENST00000525674	O95498
ENSG00000112303	ENST00000528801	E9PLK5
ENSG00000112303	ENST00000530536	E9PRD9
ENSG00000112303	ENST00000531279	E9PQ75
ENSG00000112303	ENST00000532012	E9PK31
ENSG00000112303	ENST00000532053	O95498
ENSG00000112303	ENST00000533835	B4DQB2

Expression (GTEx)

100

200

300

400

500

600

700

800

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pantothenate and CoA biosynthesis	KEGG	ko00770
Pantothenate and CoA biosynthesis	KEGG	hsa00770
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteins	REACTOME	R-HSA-163125
Metabolism	REACTOME	R-HSA-1430728
Metabolism of vitamins and cofactors	REACTOME	R-HSA-196854
Metabolism of water-soluble vitamins and cofactors	REACTOME	R-HSA-196849
Vitamin B5 (pantothenate) metabolism	REACTOME	R-HSA-199220

References

Pubmed ID	Year	Title	Citations
34769456	2021	GPI-80 Augments NF-κB Activation in Tumor Cells.	4
34769456	2021	GPI-80 Augments NF-κB Activation in Tumor Cells.	4
32853382	2020	The hematopoietic stem cell marker VNN2 is associated with chemoresistance in pediatric B-cell precursor ALL.	5
32853382	2020	The hematopoietic stem cell marker VNN2 is associated with chemoresistance in pediatric B-cell precursor ALL.	5
31776298	2019	GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma.	2
31776298	2019	GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma.	2
30066949	2018	MicroRNA‑106a regulates the proliferation and invasion of human osteosarcoma cells by targeting VNN2.	8
30066949	2018	MicroRNA‑106a regulates the proliferation and invasion of human osteosarcoma cells by targeting VNN2.	8
27569996	2016	The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood.	7
27569996	2016	The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood.	7
25465114	2015	GPI-80 defines self-renewal ability in hematopoietic stem cells during human development.	42
25465114	2015	GPI-80 defines self-renewal ability in hematopoietic stem cells during human development.	42
18095154	2008	Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.	10
18095154	2008	Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.	10
17543284	2007	Structural divergence of GPI-80 in activated human neutrophils.	5

Citation

Dessen P

VNN2 (vanin 2)

Atlas Genet Cytogenet Oncol Haematol. 2018-12-01

Online version: http://atlasgeneticsoncology.org/gene/57785/vnn2-(vanin-2)