Identity
HGNC
LOCATION
12q24.33
LOCUSID
ALIAS
KIAA0692,LEMD7,Lem4,MCPH16
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23141
MIM: 616062
HGNC: 29101
Ensembl: ENSG00000176915
Variants:
dbSNP: 23141
ClinVar: 23141
TCGA: ENSG00000176915
COSMIC: ANKLE2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35871307 | 2022 | ANKLE2-related microcephaly: A variable microcephaly syndrome resembling Zika infection. | 2 |
| 35871307 | 2022 | ANKLE2-related microcephaly: A variable microcephaly syndrome resembling Zika infection. | 2 |
| 31735666 | 2019 | Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly. | 54 |
| 31735666 | 2019 | Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly. | 54 |
| 29254732 | 2018 | LEM4/ANKLE-2 deficiency impairs post-mitotic re-localization of BAF, LAP2α and LaminA to the nucleus, causes nuclear envelope instability in telophase and leads to hyperploidy in HeLa cells. | 14 |
| 30301939 | 2018 | LEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERα pathway. | 34 |
| 29254732 | 2018 | LEM4/ANKLE-2 deficiency impairs post-mitotic re-localization of BAF, LAP2α and LaminA to the nucleus, causes nuclear envelope instability in telophase and leads to hyperploidy in HeLa cells. | 14 |
| 30301939 | 2018 | LEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERα pathway. | 34 |
| 27875273 | 2016 | SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation. | 20 |
| 27875273 | 2016 | SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation. | 20 |
| 22770216 | 2012 | Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. | 93 |
| 22770216 | 2012 | Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. | 93 |
Citation
Dessen P
ANKLE2 (ankyrin repeat and LEM domain containing 2)
Atlas Genet Cytogenet Oncol Haematol. 2019-04-01
Online version: http://atlasgeneticsoncology.org/gene/57795/ankle2-(ankyrin-repeat-and-lem-domain-containing-2)
