Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 108
MIM: 103071
HGNC: 233
Ensembl: ENSG00000078295
Variants:
dbSNP: 108
ClinVar: 108
TCGA: ENSG00000078295
COSMIC: ADCY2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000078295 | ENST00000338316 | Q08462 |
| ENSG00000078295 | ENST00000493243 | H0YA58 |
| ENSG00000078295 | ENST00000515681 | D6REB8 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA172 | GNAI1 | Gene | Pathway | associated | 19741567 | ||
| PA173 | GNAI3 | Gene | Pathway | associated | 19741567 | ||
| PA175 | GNAS | Gene | Pathway | associated | 19741567 | ||
| PA24347 | GNAI2 | Gene | Pathway | associated | 19741567 | ||
| PA446108 | Colorectal Neoplasms | Disease | ClinicalAnnotation | associated | PD | 25815774 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | ||
| PA448771 | capecitabine | Chemical | ClinicalAnnotation | associated | PD | 25815774 | |
| PA452233 | antipsychotics | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37493101 | 2023 | circSLC25A13 acts as a ceRNA to regulate AML progression via miR-616-3p/ADCY2 axis. | 1 |
| 37493101 | 2023 | circSLC25A13 acts as a ceRNA to regulate AML progression via miR-616-3p/ADCY2 axis. | 1 |
| 32447269 | 2020 | Association of adenylate cyclase-2 gene polymorphism with bipolar disorder. | 2 |
| 32893730 | 2020 | Investigation of the impact of an ADCY2 polymorphism as a predictive biomarker in bipolar disorder, suicide tendency and response to lithium carbonate therapy: the first report from Iran. | 3 |
| 32447269 | 2020 | Association of adenylate cyclase-2 gene polymorphism with bipolar disorder. | 2 |
| 32893730 | 2020 | Investigation of the impact of an ADCY2 polymorphism as a predictive biomarker in bipolar disorder, suicide tendency and response to lithium carbonate therapy: the first report from Iran. | 3 |
| 25815774 | 2015 | Clinical validation study of genetic markers for capecitabine efficacy in metastatic colorectal cancer patients. | 1 |
| 25815774 | 2015 | Clinical validation study of genetic markers for capecitabine efficacy in metastatic colorectal cancer patients. | 1 |
| 24363043 | 2014 | Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms. | 11 |
| 24363043 | 2014 | Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms. | 11 |
| 23504261 | 2013 | Differential effects of AGS3 expression on D(2L) dopamine receptor-mediated adenylyl cyclase signaling. | 10 |
| 23889134 | 2013 | AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex. | 18 |
| 23504261 | 2013 | Differential effects of AGS3 expression on D(2L) dopamine receptor-mediated adenylyl cyclase signaling. | 10 |
| 23889134 | 2013 | AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex. | 18 |
| 22461431 | 2012 | CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. | 47 |
Citation
Dessen P
ADCY2 (adenylate cyclase 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/578/adcy2-(adenylate-cyclase-2)
