Identity
HGNC
LOCATION
13q14.11
LOCUSID
ALIAS
D13S327,HHH,LNC-HC,ORC1,ORNT1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10166
MIM: 603861
HGNC: 10985
Ensembl: ENSG00000102743
Variants:
dbSNP: 10166
ClinVar: 10166
TCGA: ENSG00000102743
COSMIC: SLC25A15
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000102743 | ENST00000338625 | Q9Y619 |
| ENSG00000102743 | ENST00000417731 | Q5VZD9 |
| ENSG00000102743 | ENST00000470509 | F2Z354 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Metabolism of amino acids and derivatives | REACTOME | R-HSA-71291 |
| Urea cycle | REACTOME | R-HSA-70635 |
| Metabolism of polyamines | REACTOME | R-HSA-351202 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38450598 | 2024 | Deficiency in SLC25A15, a hypoxia-responsive gene, promotes hepatocellular carcinoma by reprogramming glutamine metabolism. | 1 |
| 38450598 | 2024 | Deficiency in SLC25A15, a hypoxia-responsive gene, promotes hepatocellular carcinoma by reprogramming glutamine metabolism. | 1 |
| 30121301 | 2018 | Structure/function relationships of the human mitochondrial ornithine/citrulline carrier by Cys site-directed mutagenesis. Relevance to mercury toxicity. | 4 |
| 30403179 | 2018 | Overexpression of SLC25A15 is involved in the proliferation of cutaneous melanoma and leads to poor prognosis. | 3 |
| 30121301 | 2018 | Structure/function relationships of the human mitochondrial ornithine/citrulline carrier by Cys site-directed mutagenesis. Relevance to mercury toxicity. | 4 |
| 30403179 | 2018 | Overexpression of SLC25A15 is involved in the proliferation of cutaneous melanoma and leads to poor prognosis. | 3 |
| 23266187 | 2013 | The mitochondrial transporter family SLC25: identification, properties and physiopathology. | 0 |
| 23266187 | 2013 | The mitochondrial transporter family SLC25: identification, properties and physiopathology. | 0 |
| 22262851 | 2012 | Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site. | 24 |
| 22292090 | 2012 | Insights into the mutation-induced HHH syndrome from modeling human mitochondrial ornithine transporter-1. | 12 |
| 22465082 | 2012 | Long-term follow-up of four patients affected by HHH syndrome. | 9 |
| 22262851 | 2012 | Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site. | 24 |
| 22292090 | 2012 | Insights into the mutation-induced HHH syndrome from modeling human mitochondrial ornithine transporter-1. | 12 |
| 22465082 | 2012 | Long-term follow-up of four patients affected by HHH syndrome. | 9 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
Citation
Dessen P
SLC25A15 (solute carrier family 25 member 15)
Atlas Genet Cytogenet Oncol Haematol. 2019-04-01
Online version: http://atlasgeneticsoncology.org/gene/57802/slc25a15-(solute-carrier-family-25-member-15)
