PCNP (PEST proteolytic signal containing nuclear protein)

2019-04-01  

Identity

HGNC
PCNP
LOCATION
3q12.3
LOCUSID
57092
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57092
MIM: 615210
HGNC: 30023
Ensembl: ENSG00000081154

Variants:

dbSNP: 57092
ClinVar: 57092
TCGA: ENSG00000081154
COSMIC: PCNP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000081154ENST00000265260Q8WW12
ENSG00000081154ENST00000460231A0A0B4J1Z9
ENSG00000081154ENST00000469941Q8WW12
ENSG00000081154ENST00000498274G5E9V9
ENSG00000081154ENST00000627393G5E9V9

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
358134722022PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer.4
358134722022PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer.4
336292942021TIPE2 and PCNP expression abnormalities in peripheral blood mononuclear cells associated with disease activity in rheumatoid arthritis: a meta-analysis.1
336292942021TIPE2 and PCNP expression abnormalities in peripheral blood mononuclear cells associated with disease activity in rheumatoid arthritis: a meta-analysis.1
325489782020PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.12
325489782020PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.12
297165282018PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.18
297165282018PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.18
147413692004NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein.27
147413692004NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein.27

Citation

Dessen P

PCNP (PEST proteolytic signal containing nuclear protein)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57806/pcnp-(pest-proteolytic-signal-containing-nuclear-protein)