TRIM2 (tripartite motif containing 2)

2019-04-01  

Identity

HGNC
LOCATION
4q31.3
LOCUSID
ALIAS
CMT2R,RNF86
FUSION GENES

Other Information

Locus ID:

NCBI: 23321
MIM: 614141
HGNC: 15974
Ensembl: ENSG00000109654

Variants:

dbSNP: 23321
ClinVar: 23321
TCGA: ENSG00000109654
COSMIC: TRIM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109654ENST00000338700Q9C040
ENSG00000109654ENST00000433687C9J084
ENSG00000109654ENST00000437508Q9C040
ENSG00000109654ENST00000441616C9JVI3
ENSG00000109654ENST00000460908A0A0J9YY97
ENSG00000109654ENST00000482578A0A0J9YW70
ENSG00000109654ENST00000494872A0A0J9YX34
ENSG00000109654ENST00000502281A0A0J9YXY2
ENSG00000109654ENST00000632856A0A0J9YW70

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369206262023Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation.1
369206262023Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation.1
360514862022Expression and Role of TRIM2 in Human Diseases.3
364817672022Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.3
360514862022Expression and Role of TRIM2 in Human Diseases.3
364817672022Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.3
337601182021Knockdown of long non‑coding RNA DLEU2 suppresses idiopathic pulmonary fibrosis by regulating the microRNA‑369‑3p/TRIM2 axis.8
337601182021Knockdown of long non‑coding RNA DLEU2 suppresses idiopathic pulmonary fibrosis by regulating the microRNA‑369‑3p/TRIM2 axis.8
329291532020Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.17
333780232020Long non-coding RNA NR2F1-AS1 promoted neuroblastoma progression through miR-493-5p/TRIM2 axis.5
329291532020Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.17
333780232020Long non-coding RNA NR2F1-AS1 promoted neuroblastoma progression through miR-493-5p/TRIM2 axis.5
307262152019TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.14
309165962019TRIM2 is a novel promoter of human colorectal cancer.12
307262152019TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.14

Citation

Dessen P

TRIM2 (tripartite motif containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57840/trim2