USP34 (ubiquitin specific peptidase 34)

2019-04-01  

Identity

HGNC
LOCATION
2p15
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 9736
MIM: 615295
HGNC: 20066
Ensembl: ENSG00000115464

Variants:

dbSNP: 9736
ClinVar: 9736
TCGA: ENSG00000115464
COSMIC: USP34

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115464ENST00000398571Q70CQ2
ENSG00000115464ENST00000411912H7C183
ENSG00000115464ENST00000436269H7C150
ENSG00000115464ENST00000453133H7BZ73
ENSG00000115464ENST00000453734A0A0C4DG73

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381672922024Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.0
381672922024Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.0
378653152023An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses.0
378653152023An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses.0
355888692022Structural Insights into the Catalytic Mechanism and Ubiquitin Recognition of USP34.3
355888692022Structural Insights into the Catalytic Mechanism and Ubiquitin Recognition of USP34.3
327832912020The deubiquitinase USP34 stabilizes SOX2 and induces cell survival and drug resistance in laryngeal squamous cell carcinoma.2
327832912020The deubiquitinase USP34 stabilizes SOX2 and induces cell survival and drug resistance in laryngeal squamous cell carcinoma.2
305851512019The ubiquitin specific protease USP34 protects the ubiquitin ligase gp78 from proteasomal degradation.2
305851512019The ubiquitin specific protease USP34 protects the ubiquitin ligase gp78 from proteasomal degradation.2
301811182018Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling.38
302217002018Expression and clinical significance of ubiquitin‑specific‑processing protease 34 in diffuse large B‑cell lymphoma.5
301811182018Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling.38
302217002018Expression and clinical significance of ubiquitin‑specific‑processing protease 34 in diffuse large B‑cell lymphoma.5
284998842017Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells.6

Citation

Dessen P

USP34 (ubiquitin specific peptidase 34)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57882/usp34-(ubiquitin-specific-peptidase-34)