GGA2 (golgi associated, gamma adaptin ear containing, ARF binding protein 2)

2019-04-01  

Identity

HGNC
LOCATION
16p12.2
LOCUSID
ALIAS
VEAR
FUSION GENES

Other Information

Locus ID:

NCBI: 23062
MIM: 606005
HGNC: 16064
Ensembl: ENSG00000103365

Variants:

dbSNP: 23062
ClinVar: 23062
TCGA: ENSG00000103365
COSMIC: GGA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103365ENST00000309859Q9UJY4
ENSG00000103365ENST00000562117I3L263
ENSG00000103365ENST00000562944I3L2C4
ENSG00000103365ENST00000563047H3BPF4
ENSG00000103365ENST00000563494H3BMN6
ENSG00000103365ENST00000567468H3BMM6
ENSG00000103365ENST00000569189H3BMN6
ENSG00000103365ENST00000569300H3BPI3
ENSG00000103365ENST00000570111H3BMN6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
TBC/RABGAPsREACTOMER-HSA-8854214

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
332064552021Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting.4
332064552021Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting.4
305789312019Integrative Genomic Analyses Identifies GGA2 as a Cooperative Driver of EGFR-Mediated Lung Tumorigenesis.8
310765152019GGA2 and RAB13 promote activity-dependent β1-integrin recycling.21
305789312019Integrative Genomic Analyses Identifies GGA2 as a Cooperative Driver of EGFR-Mediated Lung Tumorigenesis.8
310765152019GGA2 and RAB13 promote activity-dependent β1-integrin recycling.21
293585892018GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth.16
293585892018GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth.16
282892072017Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to the trans-Golgi network.18
282892072017Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to the trans-Golgi network.18
279010632016Regulation of α(2B)-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2.15
279010632016Regulation of α(2B)-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2.15
244072852014Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.11
244072852014Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.11
222919152012Analysis of Gga null mice demonstrates a non-redundant role for mammalian GGA2 during development.16

Citation

Dessen P

GGA2 (golgi associated, gamma adaptin ear containing, ARF binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57890/gga2-(golgi-associated-gamma-adaptin-ear-containing-arf-binding-protein-2)