PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase)
2019-04-01 Affiliation
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 192111
MIM: 614939
HGNC: 28763
Ensembl: ENSG00000247077
Variants:
dbSNP: 192111
ClinVar: 192111
TCGA: ENSG00000247077
COSMIC: PGAM5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000247077 | ENST00000317555 | Q96HS1 |
| ENSG00000247077 | ENST00000454808 | F5GXG4 |
| ENSG00000247077 | ENST00000498926 | Q96HS1 |
| ENSG00000247077 | ENST00000543955 | F5GXG4 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| TNF signaling pathway | KEGG | hsa04668 |
| TNF signaling pathway | KEGG | ko04668 |
| Mitophagy - animal | KEGG | ko04137 |
| Mitophagy - animal | KEGG | hsa04137 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38331384 | 2024 | ZBP1 promotes hepatocyte pyroptosis in acute liver injury by regulating the PGAM5/ROS pathway. | 0 |
| 38433252 | 2024 | Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis. | 0 |
| 38331384 | 2024 | ZBP1 promotes hepatocyte pyroptosis in acute liver injury by regulating the PGAM5/ROS pathway. | 0 |
| 38433252 | 2024 | Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis. | 0 |
| 36780919 | 2023 | PGAM5 expression levels in heart failure and protection ROS-induced oxidative stress and ferroptosis by Keap1/Nrf2. | 5 |
| 37580952 | 2023 | PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism and liver cancer proliferation. | 4 |
| 38058078 | 2023 | The Effect of PGAM5 on Regulating Mitochondrial Dysfunction in Ischemic Stroke. | 2 |
| 36780919 | 2023 | PGAM5 expression levels in heart failure and protection ROS-induced oxidative stress and ferroptosis by Keap1/Nrf2. | 5 |
| 37580952 | 2023 | PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism and liver cancer proliferation. | 4 |
| 38058078 | 2023 | The Effect of PGAM5 on Regulating Mitochondrial Dysfunction in Ischemic Stroke. | 2 |
| 34995407 | 2022 | Phosphoglycerate mutase family member 5 maintains oocyte quality via mitochondrial dynamic rearrangement during aging. | 16 |
| 35361380 | 2022 | DHEA restores mitochondrial dynamics of cumulus cells by regulating PGAM5 expression in poor ovarian responders. | 1 |
| 35921890 | 2022 | Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state. | 0 |
| 36075447 | 2022 | PGAM5 interacts with Bcl-rambo and regulates apoptosis and mitophagy. | 3 |
| 34995407 | 2022 | Phosphoglycerate mutase family member 5 maintains oocyte quality via mitochondrial dynamic rearrangement during aging. | 16 |
Citation
Dessen P
PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase)
Atlas Genet Cytogenet Oncol Haematol. 2019-04-01
Online version: http://atlasgeneticsoncology.org/gene/57925/pgam5-(pgam-family-member-5-mitochondrial-serine-threonine-protein-phosphatase)
