PEX3 (peroxisomal biogenesis factor 3)

2019-04-01  

Identity

HGNC
LOCATION
6q24.2
LOCUSID
ALIAS
PBD10A,PBD10B,TRG18

Other Information

Locus ID:

NCBI: 8504
MIM: 603164
HGNC: 8858
Ensembl: ENSG00000034693

Variants:

dbSNP: 8504
ClinVar: 8504
TCGA: ENSG00000034693
COSMIC: PEX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000034693ENST00000367591P56589
ENSG00000034693ENST00000367592Q7Z6V3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Transmembrane transport of small moleculesREACTOMER-HSA-382551
ABC-family proteins mediated transportREACTOMER-HSA-382556
ABC transporters in lipid homeostasisREACTOMER-HSA-1369062

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
350597402022rs9390123 and rs9399451 influence the DNA repair capacity of lung cancer by regulating PEX3 and PHACTR2‑AS1 expression instead of PHACTR2.3
359325522022Hypomorphic mutation of PEX3 with peroxisomal mosaicism reveals the oscillating nature of peroxisome biogenesis coupled with differential metabolic activities.1
350597402022rs9390123 and rs9399451 influence the DNA repair capacity of lung cancer by regulating PEX3 and PHACTR2‑AS1 expression instead of PHACTR2.3
359325522022Hypomorphic mutation of PEX3 with peroxisomal mosaicism reveals the oscillating nature of peroxisome biogenesis coupled with differential metabolic activities.1
348848332021Quantitative Proteomics and Differential Protein Abundance Analysis after the Depletion of PEX3 from Human Cells Identifies Additional Aspects of Protein Targeting to the ER.7
348848332021Quantitative Proteomics and Differential Protein Abundance Analysis after the Depletion of PEX3 from Human Cells Identifies Additional Aspects of Protein Targeting to the ER.7
307760932019The peroxisome biogenesis factors Pex3 and Pex19: multitasking proteins with disputed functions.27
307760932019The peroxisome biogenesis factors Pex3 and Pex19: multitasking proteins with disputed functions.27
293964262018The peroxisome biogenesis factors posttranslationally target reticulon homology domain-containing proteins to the endoplasmic reticulum membrane.14
306226612018WIPI1, BAG1, and PEX3 Autophagy-Related Genes Are Relevant Melanoma Markers.37
293964262018The peroxisome biogenesis factors posttranslationally target reticulon homology domain-containing proteins to the endoplasmic reticulum membrane.14
306226612018WIPI1, BAG1, and PEX3 Autophagy-Related Genes Are Relevant Melanoma Markers.37
265722362016Human Peroxin PEX3 Is Co-translationally Integrated into the ER and Exits the ER in Budding Vesicles.15
272955532016Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains.51
265722362016Human Peroxin PEX3 Is Co-translationally Integrated into the ER and Exits the ER in Budding Vesicles.15

Citation

Dessen P

PEX3 (peroxisomal biogenesis factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57932/pex3-(peroxisomal-biogenesis-factor-3)