P4HA3 (prolyl 4-hydroxylase subunit alpha 3)

2019-04-01  

Identity

HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 283208
MIM: 608987
HGNC: 30135
Ensembl: ENSG00000149380

Variants:

dbSNP: 283208
ClinVar: 283208
TCGA: ENSG00000149380
COSMIC: P4HA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149380ENST00000331597Q7Z4N8
ENSG00000149380ENST00000427714Q7Z4N8
ENSG00000149380ENST00000524388Q7Z4N8
ENSG00000149380ENST00000525968E9PM97
ENSG00000149380ENST00000532689H0YCC3

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Collagen biosynthesis and modifying enzymesREACTOMER-HSA-1650814

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
365881282023P4HA3 promotes clear cell renal cell carcinoma progression via the PI3K/AKT/GSK3β pathway.2
365881282023P4HA3 promotes clear cell renal cell carcinoma progression via the PI3K/AKT/GSK3β pathway.2
349590982022Prolyl 4-hydroxylase subunit alpha 3 facilitates human colon cancer growth and metastasis through the TGF-β/Smad signaling pathway.9
354332372022miR-1266-3p Suppresses Epithelial-Mesenchymal Transition in Colon Cancer by Targeting P4HA3.3
349590982022Prolyl 4-hydroxylase subunit alpha 3 facilitates human colon cancer growth and metastasis through the TGF-β/Smad signaling pathway.9
354332372022miR-1266-3p Suppresses Epithelial-Mesenchymal Transition in Colon Cancer by Targeting P4HA3.3
343871182021Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit α members in breast cancer.3
343871182021Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit α members in breast cancer.3
322208042020Prolyl 4-hydroxylase subunit alpha 3 presents a cancer promotive function in head and neck squamous cell carcinoma via regulating epithelial-mesenchymal transition.10
325397622020Age-associated genes in human mammary gland drive human breast cancer progression.14
322208042020Prolyl 4-hydroxylase subunit alpha 3 presents a cancer promotive function in head and neck squamous cell carcinoma via regulating epithelial-mesenchymal transition.10
325397622020Age-associated genes in human mammary gland drive human breast cancer progression.14
301984212018P4HA3 is Epigenetically Activated by Slug in Gastric Cancer and its Deregulation is Associated With Enhanced Metastasis and Poor Survival.19
301984212018P4HA3 is Epigenetically Activated by Slug in Gastric Cancer and its Deregulation is Associated With Enhanced Metastasis and Poor Survival.19
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

P4HA3 (prolyl 4-hydroxylase subunit alpha 3)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57943/p4ha3-(prolyl-4-hydroxylase-subunit-alpha-3)