Identity
HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
CLSS,CMS17,LRP-4,LRP10,MEGF7,SOST2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4038
MIM: 604270
HGNC: 6696
Ensembl: ENSG00000134569
Variants:
dbSNP: 4038
ClinVar: 4038
TCGA: ENSG00000134569
COSMIC: LRP4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000134569 | ENST00000378623 | O75096 |
| ENSG00000134569 | ENST00000534404 | E9PNJ5 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Extracellular matrix organization | REACTOME | R-HSA-1474244 |
| ECM proteoglycans | REACTOME | R-HSA-3000178 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38013205 | 2024 | LRP4 mutations, dental anomalies, and oral exostoses. | 0 |
| 38065285 | 2024 | LRP4-related signalling pathways and their regulatory role in neurological diseases. | 0 |
| 38101565 | 2024 | LRP4 site-specific variants in the third β-propeller domain causes congenital myasthenic syndrome type 17. | 0 |
| 38013205 | 2024 | LRP4 mutations, dental anomalies, and oral exostoses. | 0 |
| 38065285 | 2024 | LRP4-related signalling pathways and their regulatory role in neurological diseases. | 0 |
| 38101565 | 2024 | LRP4 site-specific variants in the third β-propeller domain causes congenital myasthenic syndrome type 17. | 0 |
| 37356721 | 2023 | The collagen ColQ binds to LRP4 and regulates the activation of the Muscle-Specific Kinase-LRP4 receptor complex by agrin at the neuromuscular junction. | 1 |
| 37563890 | 2023 | A variant in the LDL receptor-related protein encoding gene LRP4 underlying polydactyly and phalangeal synostosis in a family of Pakistani origin. | 0 |
| 37356721 | 2023 | The collagen ColQ binds to LRP4 and regulates the activation of the Muscle-Specific Kinase-LRP4 receptor complex by agrin at the neuromuscular junction. | 1 |
| 37563890 | 2023 | A variant in the LDL receptor-related protein encoding gene LRP4 underlying polydactyly and phalangeal synostosis in a family of Pakistani origin. | 0 |
| 33576766 | 2022 | The VWF/LRP4/αVβ3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells. | 11 |
| 34857885 | 2022 | Novel variants in the LRP4 underlying Cenani-Lenz Syndactyly syndrome. | 4 |
| 35293286 | 2022 | Knockdown of long noncoding RNA HUMT inhibits the proliferation and metastasis by regulating miR-455-5p/LRP4 axis in hepatocellular carcinoma. | 0 |
| 35362324 | 2022 | Correlation between BTG3, CASP9 and LRP4 single-nucleotide polymorphisms and susceptibility to papillary thyroid carcinoma. | 1 |
| 33576766 | 2022 | The VWF/LRP4/αVβ3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells. | 11 |
Citation
Dessen P
LRP4 (LDL receptor related protein 4)
Atlas Genet Cytogenet Oncol Haematol. 2019-04-01
Online version: http://atlasgeneticsoncology.org/gene/57973/lrp4-(ldl-receptor-related-protein-4)
