MYL6B (myosin light chain 6B)

2019-05-01  

Identity

HGNC
MYL6B
LOCATION
12q13.2
LOCUSID
140465
ALIAS
MLC1SA

Other Information

Locus ID:

NCBI: 140465
MIM: 609930
HGNC: 29823
Ensembl: ENSG00000196465

Variants:

dbSNP: 140465
ClinVar: 140465
TCGA: ENSG00000196465
COSMIC: MYL6B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196465ENST00000550443P14649
ENSG00000196465ENST00000550443A0A024RB31
ENSG00000196465ENST00000551834F8VSA2
ENSG00000196465ENST00000552568F8W1I5
ENSG00000196465ENST00000553066P14649
ENSG00000196465ENST00000553066A0A024RB31

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
Muscle contractionREACTOMER-HSA-397014
Smooth Muscle ContractionREACTOMER-HSA-445355

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
294397192018MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development.9
294397192018MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development.9
185876282008IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100B.11
185876282008IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100B.11

Citation

Dessen P

MYL6B (myosin light chain 6B)

Atlas Genet Cytogenet Oncol Haematol. 2019-05-01

Online version: http://atlasgeneticsoncology.org/gene/57982/myl6b-(myosin-light-chain-6b)