ZCCHC4 (zinc finger CCHC-type containing 4)

2019-05-01  

Identity

HGNC
ZCCHC4
LOCATION
4p15.2
LOCUSID
29063
ALIAS
HSPC052,ZGRF4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29063
MIM: 611792
HGNC: 22917
Ensembl: ENSG00000168228

Variants:

dbSNP: 29063
ClinVar: 29063
TCGA: ENSG00000168228
COSMIC: ZCCHC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168228ENST00000302874Q9H5U6
ENSG00000168228ENST00000505412H0Y8V8
ENSG00000168228ENST00000507760Q9H5U6
ENSG00000168228ENST00000612982A0A087X0K5

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
383268632024The epigenetic downregulation of LncGHRLOS mediated by RNA m6A methylase ZCCHC4 promotes colorectal cancer tumorigenesis.1
383268632024The epigenetic downregulation of LncGHRLOS mediated by RNA m6A methylase ZCCHC4 promotes colorectal cancer tumorigenesis.1
376061622023ZCCHC4 Promotes Osteosarcoma Progression by Upregulating ITGB1.0
376061622023ZCCHC4 Promotes Osteosarcoma Progression by Upregulating ITGB1.0
358538662022RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis.12
358538662022RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis.12
317996052020The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA.75
317996052020The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA.75
305319102019N(6-)Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation.192
316950392019Structure and regulation of ZCCHC4 in m(6)A-methylation of 28S rRNA.60
305319102019N(6-)Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation.192
316950392019Structure and regulation of ZCCHC4 in m(6)A-methylation of 28S rRNA.60

Citation

Dessen P

ZCCHC4 (zinc finger CCHC-type containing 4)

Atlas Genet Cytogenet Oncol Haematol. 2019-05-01

Online version: http://atlasgeneticsoncology.org/gene/57985/zcchc4-(zinc-finger-cchc-type-containing-4)