TNRC6B (trinucleotide repeat containing adaptor 6B)

2019-05-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
GDSBA
FUSION GENES

Other Information

Locus ID:

NCBI: 23112
MIM: 610740
HGNC: 29190
Ensembl: ENSG00000100354

Variants:

dbSNP: 23112
ClinVar: 23112
TCGA: ENSG00000100354
COSMIC: TNRC6B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100354ENST00000301923Q9UPQ9
ENSG00000100354ENST00000301923A0A024R1N5
ENSG00000100354ENST00000335727Q9UPQ9
ENSG00000100354ENST00000402203Q9UPQ9
ENSG00000100354ENST00000402203A0A024R1N5
ENSG00000100354ENST00000441751B0QYM5
ENSG00000100354ENST00000446273H0Y720
ENSG00000100354ENST00000454349Q9UPQ9

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GAB1 signalosomeREACTOMER-HSA-180292
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Transcription and TranslationREACTOMER-HSA-1912408
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Gene Silencing by RNAREACTOMER-HSA-211000
Post-transcriptional silencing by small RNAsREACTOMER-HSA-426496
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oncogene Induced SenescenceREACTOMER-HSA-2559585
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384042512024Novel variants in TNRC6B cause global developmental delay with speech and behavioral abnormalities, short stature, low body weight, café-au-lait spots, and metabolic abnormality.1
384042512024Novel variants in TNRC6B cause global developmental delay with speech and behavioral abnormalities, short stature, low body weight, café-au-lait spots, and metabolic abnormality.1
341082312021Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.5
341082312021Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.5
321522502020Pathogenic variants in TNRC6B cause a genetic disorder characterised by developmental delay/intellectual disability and a spectrum of neurobehavioural phenotypes including autism and ADHD.8
324505212020FOXA1-induced LINC01207 facilitates head and neck squamous cell carcinoma via up-regulation of TNRC6B.8
321522502020Pathogenic variants in TNRC6B cause a genetic disorder characterised by developmental delay/intellectual disability and a spectrum of neurobehavioural phenotypes including autism and ADHD.8
324505212020FOXA1-induced LINC01207 facilitates head and neck squamous cell carcinoma via up-regulation of TNRC6B.8
309975012019TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.9
316706062019Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.10
309975012019TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.9
316706062019Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.10
294759682018miRNA-Processing Gene Methylation and Cancer Risk.11
297435412018Association of BET1L and TNRC6B with uterine leiomyoma risk and its relevant clinical features in Han Chinese population.3
294759682018miRNA-Processing Gene Methylation and Cancer Risk.11

Citation

Dessen P

TNRC6B (trinucleotide repeat containing adaptor 6B)

Atlas Genet Cytogenet Oncol Haematol. 2019-05-01

Online version: http://atlasgeneticsoncology.org/gene/57998/tnrc6b-(trinucleotide-repeat-containing-adaptor-6b)