Identity
HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
RRP41,RRP41A,Rrp41p,SKI6,Ski6p,hRrp41p,p12A
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54512
MIM: 606491
HGNC: 18189
Ensembl: ENSG00000178896
Variants:
dbSNP: 54512
ClinVar: 54512
TCGA: ENSG00000178896
COSMIC: EXOSC4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000178896 | ENST00000316052 | Q9NPD3 |
| ENSG00000178896 | ENST00000525936 | E9PPI9 |
| ENSG00000178896 | ENST00000527954 | E9PI41 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38913281 | 2024 | RUNX3 exerts tumor-suppressive role through inhibiting EXOSC4 expression. | 0 |
| 38913281 | 2024 | RUNX3 exerts tumor-suppressive role through inhibiting EXOSC4 expression. | 0 |
| 35008922 | 2022 | RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival. | 4 |
| 35008922 | 2022 | RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival. | 4 |
| 30155936 | 2018 | EXOSC4 functions as a potential oncogene in development and progression of colorectal cancer. | 8 |
| 30155936 | 2018 | EXOSC4 functions as a potential oncogene in development and progression of colorectal cancer. | 8 |
| 17545563 | 2007 | Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. | 48 |
| 17545563 | 2007 | Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. | 48 |
| 12419256 | 2002 | Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. | 28 |
| 12419256 | 2002 | Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. | 28 |
Citation
Dessen P
EXOSC4 (exosome component 4)
Atlas Genet Cytogenet Oncol Haematol. 2019-05-01
Online version: http://atlasgeneticsoncology.org/gene/58020/exosc4-(exosome-component-4)
