ECSIT (ECSIT signaling integrator)

2019-05-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
SITPEC
FUSION GENES

Other Information

Locus ID:

NCBI: 51295
MIM: 608388
HGNC: 29548
Ensembl: ENSG00000130159

Variants:

dbSNP: 51295
ClinVar: 51295
TCGA: ENSG00000130159
COSMIC: ECSIT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130159ENST00000252440Q9BQ95
ENSG00000130159ENST00000270517Q9BQ95
ENSG00000130159ENST00000417981Q9BQ95
ENSG00000130159ENST00000585318J3KTF5
ENSG00000130159ENST00000586149K7EM98
ENSG00000130159ENST00000588998K7ESM8
ENSG00000130159ENST00000590480K7EPL5
ENSG00000130159ENST00000591104Q9BQ95
ENSG00000130159ENST00000592312K7EN32
ENSG00000130159ENST00000592571K7EJG5
ENSG00000130159ENST00000592665K7EJI1
ENSG00000130159ENST00000593231K7EIK2

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Respiratory electron transportREACTOMER-HSA-611105
Complex I biogenesisREACTOMER-HSA-6799198

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383265542024ECSIT facilitates memory CD8(+) T cell development by mediating fumarate synthesis during viral infection and tumorigenesis.0
383265542024ECSIT facilitates memory CD8(+) T cell development by mediating fumarate synthesis during viral infection and tumorigenesis.0
374094302023ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein.2
374094302023ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein.2
330541382021No association between ECSIT germline mutations and hemophagocytic lymphohistiocytosis in natural killer/T-cell lymphoma.0
340326372021ECSIT is a critical limiting factor for cardiac function.5
330541382021No association between ECSIT germline mutations and hemophagocytic lymphohistiocytosis in natural killer/T-cell lymphoma.0
340326372021ECSIT is a critical limiting factor for cardiac function.5
316201282019CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1.15
316201282019CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1.15
292913522018Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma.32
292913522018Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma.32
252283972015ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses.15
253559512015Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling.18
254495732015Hepatitis B virus X protein increases the IL-1β-induced NF-κB activation via interaction with evolutionarily conserved signaling intermediate in Toll pathways (ECSIT).10

Citation

Dessen P

ECSIT (ECSIT signaling integrator)

Atlas Genet Cytogenet Oncol Haematol. 2019-05-01

Online version: http://atlasgeneticsoncology.org/gene/58024/ecsit-(ecsit-signaling-integrator)