SALL1 (spalt like transcription factor 1)

2019-08-01  

Identity

HGNC
LOCATION
16q12.1
LOCUSID
ALIAS
HEL-S-89,HSAL1,Sal-1,TBS,ZNF794

Other Information

Locus ID:

NCBI: 6299
MIM: 602218
HGNC: 10524
Ensembl: ENSG00000103449

Variants:

dbSNP: 6299
ClinVar: 6299
TCGA: ENSG00000103449
COSMIC: SALL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103449ENST00000251020Q9NSC2
ENSG00000103449ENST00000440970Q9NSC2
ENSG00000103449ENST00000566102H3BQ32
ENSG00000103449ENST00000570206H3BSM9

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of pluripotent stem cellsREACTOMER-HSA-452723
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferationREACTOMER-HSA-2892247

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
316937702023miR-4286 promotes prostate cancer progression by targeting the expression of SALL1.7
368331852023Chromosomal Microarray Analysis Identifies a Novel SALL1 Deletion, Supporting the Association of Haploinsufficiency with a Mild Phenotype of Townes-Brocks Syndrome.2
316937702023miR-4286 promotes prostate cancer progression by targeting the expression of SALL1.7
368331852023Chromosomal Microarray Analysis Identifies a Novel SALL1 Deletion, Supporting the Association of Haploinsufficiency with a Mild Phenotype of Townes-Brocks Syndrome.2
362529102022Townes-Brocks syndrome with craniosynostosis in two siblings.1
362529102022Townes-Brocks syndrome with craniosynostosis in two siblings.1
330984862021SOX2/SALL4 stemness axis modulates Notch signaling genes to maintain self-renewal capacity of esophageal squamous cell carcinoma.6
342575352021Hsa_circ_0043265 Restrains Cell Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting the miR-1243/SALL1 Axis.2
330984862021SOX2/SALL4 stemness axis modulates Notch signaling genes to maintain self-renewal capacity of esophageal squamous cell carcinoma.6
342575352021Hsa_circ_0043265 Restrains Cell Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting the miR-1243/SALL1 Axis.2
310402652019Spalt-Like Transcription Factor 1 (SALL1) Gene Expression Inhibits Cell Proliferation and Cell Migration of Human Glioma Cells Through the Wnt/β-Catenin Signaling Pathway.12
310402652019Spalt-Like Transcription Factor 1 (SALL1) Gene Expression Inhibits Cell Proliferation and Cell Migration of Human Glioma Cells Through the Wnt/β-Catenin Signaling Pathway.12
293950722018Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.18
296255652018SALL1 functions as a tumor suppressor in breast cancer by regulating cancer cell senescence and metastasis through the NuRD complex.24
293950722018Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.18

Citation

Dessen P

SALL1 (spalt like transcription factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58026/sall1-(spalt-like-transcription-factor-1)