Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23601
MIM: 604987
HGNC: 2054
Ensembl: ENSG00000258227
Variants:
dbSNP: 23601
ClinVar: 23601
TCGA: ENSG00000258227
COSMIC: CLEC5A
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| DAP12 interactions | REACTOME | R-HSA-2172127 |
| Neutrophil degranulation | REACTOME | R-HSA-6798695 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36571274 | 2023 | CLEC5A expression can be triggered by spike glycoprotein and may be a potential target for COVID-19 therapy. | 3 |
| 36856214 | 2023 | [Overexpression of CLEC5A inhibits cell proliferation and metastasis and reverses epithelial-mesenchymal transition in hepatocellular carcinoma]. | 0 |
| 36571274 | 2023 | CLEC5A expression can be triggered by spike glycoprotein and may be a potential target for COVID-19 therapy. | 3 |
| 36856214 | 2023 | [Overexpression of CLEC5A inhibits cell proliferation and metastasis and reverses epithelial-mesenchymal transition in hepatocellular carcinoma]. | 0 |
| 35252461 | 2022 | Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages' Function but Does Not Trigger the Adaptive T Cell Immune Response. | 4 |
| 35820906 | 2022 | CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation. | 19 |
| 35252461 | 2022 | Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages' Function but Does Not Trigger the Adaptive T Cell Immune Response. | 4 |
| 35820906 | 2022 | CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation. | 19 |
| 31591460 | 2020 | CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma. | 15 |
| 32033754 | 2020 | CLEC5A promotes the proliferation of gastric cancer cells by activating the PI3K/AKT/mTOR pathway. | 9 |
| 32152943 | 2020 | CLEC5A: A Promiscuous Pattern Recognition Receptor to Microbes and Beyond. | 10 |
| 32476786 | 2020 | Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn's disease. | 5 |
| 31591460 | 2020 | CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma. | 15 |
| 32033754 | 2020 | CLEC5A promotes the proliferation of gastric cancer cells by activating the PI3K/AKT/mTOR pathway. | 9 |
| 32152943 | 2020 | CLEC5A: A Promiscuous Pattern Recognition Receptor to Microbes and Beyond. | 10 |
Citation
Dessen P
CLEC5A (C-type lectin domain containing 5A)
Atlas Genet Cytogenet Oncol Haematol. 2019-08-01
Online version: http://atlasgeneticsoncology.org/gene/58034/clec5a-(c-type-lectin-domain-containing-5a)
