POLR1D (RNA polymerase I and III subunit D)

2019-08-01  

Identity

HGNC
POLR1D
LOCATION
13q12.2
LOCUSID
51082
ALIAS
AC19,POLR1C,RPA16,RPA9,RPAC2,RPC16,RPO1-3,TCS2

Other Information

Locus ID:

NCBI: 51082
MIM: 613715
HGNC: 20422
Ensembl: ENSG00000186184

Variants:

dbSNP: 51082
ClinVar: 51082
TCGA: ENSG00000186184
COSMIC: POLR1D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186184ENST00000302979P0DPB6
ENSG00000186184ENST00000399696A0A0R4J2F3
ENSG00000186184ENST00000399697P0DPB5
ENSG00000186184ENST00000465887A0A087X0U2
ENSG00000186184ENST00000489647A0A087X0U2
ENSG00000186184ENST00000621089A0A087WTY1
ENSG00000186184ENST00000630983Q7Z776
ENSG00000186184ENST00000636817A0A1B0GUZ5
ENSG00000186184ENST00000637071A0A087WTY1
ENSG00000186184ENST00000637180A0A087WTY1

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
RNA polymeraseKEGGko03020
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
RNA polymeraseKEGGhsa03020
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Metabolic pathwaysKEGGhsa01100
RNA polymerase III, eukaryotesKEGGhsa_M00181
RNA polymerase I, eukaryotesKEGGhsa_M00182
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
RNA polymerase III, eukaryotesKEGGM00181
RNA polymerase I, eukaryotesKEGGM00182
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
RNA Polymerase I Promoter EscapeREACTOMER-HSA-73772
RNA Polymerase I Chain ElongationREACTOMER-HSA-73777
RNA Polymerase I Transcription TerminationREACTOMER-HSA-73863
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription InitiationREACTOMER-HSA-76046
RNA Polymerase III Transcription Initiation From Type 1 PromoterREACTOMER-HSA-76061
RNA Polymerase III Transcription Initiation From Type 2 PromoterREACTOMER-HSA-76066
RNA Polymerase III Transcription Initiation From Type 3 PromoterREACTOMER-HSA-76071
RNA Polymerase III Chain ElongationREACTOMER-HSA-73780
RNA Polymerase III Transcription TerminationREACTOMER-HSA-73980
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
B-WICH complex positively regulates rRNA expressionREACTOMER-HSA-5250924

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
388449752024POLR1D silencing suppresses lung cancer cells proliferation and migration via inhibition of PI3K-Akt pathway.0
388449752024POLR1D silencing suppresses lung cancer cells proliferation and migration via inhibition of PI3K-Akt pathway.0
356565832022A clinically-relevant residue of POLR1D is required for Drosophila development.1
356565832022A clinically-relevant residue of POLR1D is required for Drosophila development.1
316492762020POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4.37
317223312020Expression and Clinical Significance of POLR1D in Colorectal Cancer.4
320877352020Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer.19
316492762020POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4.37
317223312020Expression and Clinical Significance of POLR1D in Colorectal Cancer.4
320877352020Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer.19
305822212019POLR1D promotes colorectal cancer progression and predicts poor prognosis of patients.14
305822212019POLR1D promotes colorectal cancer progression and predicts poor prognosis of patients.14
257901622016Treacher Collins syndrome: a clinical and molecular study based on a large series of patients.50
257901622016Treacher Collins syndrome: a clinical and molecular study based on a large series of patients.50
253487282015Whole exome sequencing identifies a POLRID mutation segregating in a father and two daughters with findings of Klippel-Feil and Treacher Collins syndromes.6

Citation

Dessen P

POLR1D (RNA polymerase I and III subunit D)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58044/new-content/gene-explorer/