SLC17A7 (solute carrier family 17 member 7)

2019-08-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
BNPI,VGLUT1

Other Information

Locus ID:

NCBI: 57030
MIM: 605208
HGNC: 16704
Ensembl: ENSG00000104888

Variants:

dbSNP: 57030
ClinVar: 57030
TCGA: ENSG00000104888
COSMIC: SLC17A7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104888ENST00000221485Q9P2U7
ENSG00000104888ENST00000596689M0R1S5
ENSG00000104888ENST00000600601Q9P2U7

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Nicotine addictionKEGGhsa05033
Nicotine addictionKEGGko05033
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Glutamate Neurotransmitter Release CycleREACTOMER-HSA-210500
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Organic anion transportersREACTOMER-HSA-428643

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
316638542019A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency.10
316638542019A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency.10
298909942018Network-based analysis of oligodendrogliomas predicts novel cancer gene candidates within the region of the 1p/19q co-deletion.21
298909942018Network-based analysis of oligodendrogliomas predicts novel cancer gene candidates within the region of the 1p/19q co-deletion.21
268361592016JNK: A Putative Link Between Insulin Signaling and VGLUT1 in Alzheimer's Disease.4
270292262016Genetic variation in SLC17A7 promoter associated with response to sport-related concussions.7
272588192016Down-regulation of glutamatergic terminals (VGLUT1) driven by Aβ in Alzheimer's disease.18
268361592016JNK: A Putative Link Between Insulin Signaling and VGLUT1 in Alzheimer's Disease.4
270292262016Genetic variation in SLC17A7 promoter associated with response to sport-related concussions.7
272588192016Down-regulation of glutamatergic terminals (VGLUT1) driven by Aβ in Alzheimer's disease.18
257490332015Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene.35
257490332015Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene.35
225102712012Glutamatergic and GABAergic innervation of human gonadotropin-releasing hormone-I neurons.10
230224702012Alterations in the expression of PSA-NCAM and synaptic proteins in the dorsolateral prefrontal cortex of psychiatric disorder patients.44
225102712012Glutamatergic and GABAergic innervation of human gonadotropin-releasing hormone-I neurons.10

Citation

Dessen P

SLC17A7 (solute carrier family 17 member 7)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58062/slc17a7-(solute-carrier-family-17-member-7)