PIN4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4)

2019-08-01  

Identity

HGNC
PIN4
LOCATION
Xq13.1
LOCUSID
5303
ALIAS
EPVH,PAR14,PAR17

Other Information

Locus ID:

NCBI: 5303
MIM: 300252
HGNC: 8992
Ensembl: ENSG00000102309

Variants:

dbSNP: 5303
ClinVar: 5303
TCGA: ENSG00000102309
COSMIC: PIN4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102309ENST00000218432J3KMW3
ENSG00000102309ENST00000373662D6RFY5
ENSG00000102309ENST00000373669Q9Y237
ENSG00000102309ENST00000423432Q9Y237
ENSG00000102309ENST00000439980H0Y4T6
ENSG00000102309ENST00000446576H0Y610
ENSG00000102309ENST00000496835H0Y8P6
ENSG00000102309ENST00000652108A0A494C021
ENSG00000102309ENST00000664196Q9Y237

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365835142023Par14 interacts with the androgen receptor, augmenting both its transcriptional activity and prostate cancer proliferation.2
365835142023Par14 interacts with the androgen receptor, augmenting both its transcriptional activity and prostate cancer proliferation.2
305679872019Parvulin 14 and Parvulin 17 Bind to HBx and cccDNA and Upregulate Hepatitis B Virus Replication from cccDNA to Virion in an HBx-Dependent Manner.31
305679872019Parvulin 14 and Parvulin 17 Bind to HBx and cccDNA and Upregulate Hepatitis B Virus Replication from cccDNA to Virion in an HBx-Dependent Manner.31
303143612018The Multiple Roles of Peptidyl Prolyl Isomerases in Brain Cancer.4
303143612018The Multiple Roles of Peptidyl Prolyl Isomerases in Brain Cancer.4
255956592015Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1.10
256455912015Human DNA-binding peptidyl-prolyl cis/trans isomerase Par14 is cell cycle dependently expressed and associates with chromatin in vivo.7
259400902015Parvulin 17-catalyzed Tubulin Polymerization Is Regulated by Calmodulin in a Calcium-dependent Manner.5
255956592015Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1.10
256455912015Human DNA-binding peptidyl-prolyl cis/trans isomerase Par14 is cell cycle dependently expressed and associates with chromatin in vivo.7
259400902015Parvulin 17-catalyzed Tubulin Polymerization Is Regulated by Calmodulin in a Calcium-dependent Manner.5
237207712013Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.12
237207712013Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.12
165222112006Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation.21

Citation

Dessen P

PIN4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58064/pin4-(peptidylprolyl-cis-trans-isomerase-nima-interacting-4)