Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 84618
MIM: 610525
HGNC: 17819
Ensembl: ENSG00000116981
Variants:
dbSNP: 84618
ClinVar: 84618
TCGA: ENSG00000116981
COSMIC: NT5C1A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000116981 | ENST00000235628 | Q9BXI3 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | 26906009 | ||
| PA449027 | cladribine | Chemical | ClinicalAnnotation | associated | 26906009 | ||
| PA449748 | gemcitabine | Chemical | ClinicalAnnotation | associated | 26906009 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 30709769 | 2019 | Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites. | 14 |
| 31024569 | 2019 | Anti-NT5c1A Autoantibodies as Biomarkers in Inclusion Body Myositis. | 19 |
| 30709769 | 2019 | Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites. | 14 |
| 31024569 | 2019 | Anti-NT5c1A Autoantibodies as Biomarkers in Inclusion Body Myositis. | 19 |
| 25857661 | 2016 | Seropositivity for NT5c1A antibody in sporadic inclusion body myositis predicts more severe motor, bulbar and respiratory involvement. | 27 |
| 25892010 | 2016 | Cytosolic 5'-Nucleotidase 1A As a Target of Circulating Autoantibodies in Autoimmune Diseases. | 29 |
| 26906009 | 2016 | Pharmacogenetic characterization of naturally occurring germline NT5C1A variants to chemotherapeutic nucleoside analogs. | 1 |
| 25857661 | 2016 | Seropositivity for NT5c1A antibody in sporadic inclusion body myositis predicts more severe motor, bulbar and respiratory involvement. | 27 |
| 25892010 | 2016 | Cytosolic 5'-Nucleotidase 1A As a Target of Circulating Autoantibodies in Autoimmune Diseases. | 29 |
| 26906009 | 2016 | Pharmacogenetic characterization of naturally occurring germline NT5C1A variants to chemotherapeutic nucleoside analogs. | 1 |
| 21873433 | 2011 | Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. | 32 |
| 21873433 | 2011 | Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. | 32 |
| 19352542 | 2009 | Expression of cytosolic 5' nucleotidase does not correlate with expression of oxidative metabolism marker: myoglobine in human skeletal muscles. | 1 |
| 19352542 | 2009 | Expression of cytosolic 5' nucleotidase does not correlate with expression of oxidative metabolism marker: myoglobine in human skeletal muscles. | 1 |
| 17065091 | 2006 | Cell cycle dependent regulation of deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I activity in MOLT-4 cells. | 0 |
Citation
Dessen P
NT5C1A (5-nucleotidase, cytosolic IA)
Atlas Genet Cytogenet Oncol Haematol. 2019-08-01
Online version: http://atlasgeneticsoncology.org/gene/58069/nt5c1a-(5-nucleotidase-cytosolic-ia)
