ST6GALNAC3 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3)

2019-08-01  

Identity

LOCATION
1p31.1
LOCUSID
ALIAS
PRO7177,SIAT7C,ST6GALNACIII,STY

Other Information

Locus ID:

NCBI: 256435
MIM: 610133
HGNC: 19343
Ensembl: ENSG00000184005

Variants:

dbSNP: 256435
ClinVar: 256435
TCGA: ENSG00000184005
COSMIC: ST6GALNAC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184005ENST00000328299Q8NDV1
ENSG00000184005ENST00000621530A0A087WWK2

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Glycosphingolipid biosynthesis - ganglio seriesKEGGko00604
Glycosphingolipid biosynthesis - ganglio seriesKEGGhsa00604
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Sialic acid metabolismREACTOMER-HSA-4085001
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
Termination of O-glycan biosynthesisREACTOMER-HSA-977068

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
344614392021Depletion of ST6GALNACIII retards A549 non-small cell lung cancer cell proliferation by downregulating transferrin receptor protein 1 expression.2
344614392021Depletion of ST6GALNACIII retards A549 non-small cell lung cancer cell proliferation by downregulating transferrin receptor protein 1 expression.2
294657882018Biomarker potential of ST6GALNAC3 and ZNF660 promoter hypermethylation in prostate cancer tissue and liquid biopsies.31
294657882018Biomarker potential of ST6GALNAC3 and ZNF660 promoter hypermethylation in prostate cancer tissue and liquid biopsies.31
247402072014Genome-wide association study of circulating vitamin D-binding protein.32
247402072014Genome-wide association study of circulating vitamin D-binding protein.32
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
204214872010Genome-wide association identifies candidate genes that influence the human electroencephalogram.38
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
204214872010Genome-wide association identifies candidate genes that influence the human electroencephalogram.38
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.145
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.145
161698742005Molecular cloning and expression of human ST6GalNAc III: restricted tissue distribution and substrate specificity.16
161698742005Molecular cloning and expression of human ST6GalNAc III: restricted tissue distribution and substrate specificity.16

Citation

Dessen P

ST6GALNAC3 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58076/st6galnac3-(st6-n-acetylgalactosaminide-alpha-2-6-sialyltransferase-3)