H1-0 (H1.0 linker histone)

2019-08-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
H1.0,H10,H1F0,H1FV

Other Information

Locus ID:

NCBI: 3005
MIM: 142708
HGNC: 4714
Ensembl: ENSG00000189060

Variants:

dbSNP: 3005
ClinVar: 3005
TCGA: ENSG00000189060
COSMIC: H1-0

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189060ENST00000340857P07305

Pathways

PathwaySourceExternal ID
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptosis induced DNA fragmentationREACTOMER-HSA-140342
Activation of DNA fragmentation factorREACTOMER-HSA-211227
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)REACTOMER-HSA-2559584

References

Pubmed IDYearTitleCitations
369280682023Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.2
369280682023Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.2
350669472022Structure, dynamics, and stability of the globular domain of human linker histone H1.0 and the role of positive charges.3
350727992022Analysis of histone variant constraint and tissue expression suggests five potential novel human disease genes: H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0.3
350669472022Structure, dynamics, and stability of the globular domain of human linker histone H1.0 and the role of positive charges.3
350727992022Analysis of histone variant constraint and tissue expression suggests five potential novel human disease genes: H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0.3
332991812021Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.99
334320552021Linker histone defines structure and self-association behaviour of the 177 bp human chromatosome.15
336675092021The Dynamic Influence of Linker Histone Saturation within the Poly-Nucleosome Array.11
332991812021Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.99
334320552021Linker histone defines structure and self-association behaviour of the 177 bp human chromatosome.15
336675092021The Dynamic Influence of Linker Histone Saturation within the Poly-Nucleosome Array.11
299826882018Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage.35
304308262018Binding Affinity and Function of the Extremely Disordered Protein Complex Containing Human Linker Histone H1.0 and Its Chaperone ProTα.17
299826882018Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage.35

Citation

Dessen P

H1-0 (H1.0 linker histone)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58100/h1-0-(h1-0-linker-histone)