SIKE1 (suppressor of IKBKE 1)

2019-08-01  

Identity

HGNC
LOCATION
1p13.2
LOCUSID
ALIAS
SIKE

Other Information

Locus ID:

NCBI: 80143
MIM: 611656
HGNC: 26119
Ensembl: ENSG00000052723

Variants:

dbSNP: 80143
ClinVar: 80143
TCGA: ENSG00000052723
COSMIC: SIKE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000052723ENST00000060969Q9BRV8
ENSG00000052723ENST00000369528Q9BRV8

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF3-dependent IRF activation pathwayREACTOMER-HSA-918233
TRAF6 mediated IRF7 activationREACTOMER-HSA-933541

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
304871592019Prognostic values of inhibitory κB kinases mRNA expression in human gastric cancer.4
304871592019Prognostic values of inhibitory κB kinases mRNA expression in human gastric cancer.4
272493212016Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy.33
272493212016Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy.33
236496222013Mechanism of endogenous regulation of the type I interferon response by suppressor of IκB kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1).8
236496222013Mechanism of endogenous regulation of the type I interferon response by suppressor of IκB kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1).8
162810572005SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.66
162810572005SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.66

Citation

Dessen P

SIKE1 (suppressor of IKBKE 1)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58111/sike1-(suppressor-of-ikbke-1)