Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 57721
MIM: 616504
HGNC: 29330
Ensembl: ENSG00000145388
Variants:
dbSNP: 57721
ClinVar: 57721
TCGA: ENSG00000145388
COSMIC: METTL14
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| Processing of Capped Intron-Containing Pre-mRNA | REACTOME | R-HSA-72203 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37594665 | 2024 | METTL14 drives growth and metastasis of non-small cell lung cancer by regulating pri-miR-93-5p maturation and TXNIP expression. | 1 |
| 37972448 | 2024 | CircMETTL14(11)S upregulated METTL14 and induced CXCR4 to aggravate endothelial inflammation and atherosclerosis. | 0 |
| 38131226 | 2024 | Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review). | 0 |
| 38146129 | 2024 | METTL14 promotes IL-6-induced viability, glycolysis and inflammation in HaCaT cells via the m6A modification of TRIM27. | 1 |
| 38195017 | 2024 | Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition. | 0 |
| 38197667 | 2024 | Glycolysis Induced by METTL14 Is Essential for Macrophage Phagocytosis and Phenotype in Cervical Cancer. | 0 |
| 38229320 | 2024 | METTL14-mediated lncRNA XIST silencing alleviates GDM progression by facilitating trophoblast cell proliferation and migration via the miR-497-5p/FOXO1 axis. | 0 |
| 38279741 | 2024 | Compression Promotes the Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Regulating METTL14-mediated IGF1. | 0 |
| 38319733 | 2024 | METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2. | 1 |
| 38387756 | 2024 | Lnc-PLCB1 is stabilized by METTL14 induced m6A modification and inhibits Helicobacter pylori mediated gastric cancer by destabilizing DDX21. | 1 |
| 38403332 | 2024 | FoxO1 promotes ovarian cancer by increasing transcription and METTL14-mediated m(6)A modification of SMC4. | 2 |
| 38421707 | 2024 | METTL14-Mediated m6a Modification of CDKN2A Promotes the Development of Retinoblastoma by Inhibiting the p53 Pathway. | 1 |
| 38627387 | 2024 | METTL14 downregulation drives S100A4(+) monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression. | 1 |
| 38679464 | 2024 | N6-methyladenosine methylation on FSCN1 mediated by METTL14/IGF2BP3 contributes to human papillomavirus type 16-infected cervical squamous cell carcinoma. | 0 |
| 38738555 | 2024 | METTL14 decreases FTH1 mRNA stability via m6A methylation to promote sorafenib-induced ferroptosis of cervical cancer. | 0 |
Citation
Dessen P
METTL14 (methyltransferase 14, N6-adenosine-methyltransferase subunit)
Atlas Genet Cytogenet Oncol Haematol. 2019-08-01
Online version: http://atlasgeneticsoncology.org/gene/58112
