CERT1 (ceramide transporter 1)

2019-08-01  

Identity

HGNC
LOCATION
5q13.3
LOCUSID
ALIAS
CERT,CERTL,COL4A3BP,GPBP,MRD34,STARD11

Other Information

Locus ID:

NCBI: 10087
MIM: 604677
HGNC: 2205
Ensembl: ENSG00000113163

Variants:

dbSNP: 10087
ClinVar: 10087
TCGA: ENSG00000113163
COSMIC: CERT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113163ENST00000261415Q9Y5P4
ENSG00000113163ENST00000357457A0A0A0MRE4
ENSG00000113163ENST00000380494A0A2U3TZL3
ENSG00000113163ENST00000405807Q9Y5P4
ENSG00000113163ENST00000508692A0A2R8Y773
ENSG00000113163ENST00000508809H0Y9J1
ENSG00000113163ENST00000642225A0A2R8YCI0
ENSG00000113163ENST00000642488A0A2R8YE59
ENSG00000113163ENST00000642556A0A2R8Y7C5
ENSG00000113163ENST00000642809A0A2R8Y5S9
ENSG00000113163ENST00000643158A0A2R8Y7Q9
ENSG00000113163ENST00000643380A0A2R8YDX6
ENSG00000113163ENST00000643773A0A2R8Y3S9
ENSG00000113163ENST00000643780Q9Y5P4
ENSG00000113163ENST00000644072Q9Y5P4
ENSG00000113163ENST00000644128A0A2R8Y5G0
ENSG00000113163ENST00000644377A0A2R8Y5H3
ENSG00000113163ENST00000644445Q9Y5P4
ENSG00000113163ENST00000644445A0A024RAJ5
ENSG00000113163ENST00000644516A0A2R8YEA4
ENSG00000113163ENST00000644912A0A2R8YE18
ENSG00000113163ENST00000645483Q9Y5P4
ENSG00000113163ENST00000645483A0A024RAJ5
ENSG00000113163ENST00000645866A0A2R8YEK8
ENSG00000113163ENST00000646172A0A2R8YFA1
ENSG00000113163ENST00000646302A0A2R8YFI2
ENSG00000113163ENST00000646511Q9Y5P4
ENSG00000113163ENST00000646511A0A024RAJ5
ENSG00000113163ENST00000646713A0A2R8Y5S9

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661

References

Pubmed IDYearTitleCitations
146852292003Molecular machinery for non-vesicular trafficking of ceramide.293
217314892011The lipid transfer protein CERT interacts with the Chlamydia inclusion protein IncD and participates to ER-Chlamydia inclusion membrane contact sites.105
168959112006Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT.96
219092602011Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development.83
175919192007Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein.77
165716692006Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein.74
181848062008Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.60
155964492005CERT mediates intermembrane transfer of various molecular species of ceramides.56
174426652007Interorganelle trafficking of ceramide is regulated by phosphorylation-dependent cooperativity between the PH and START domains of CERT.40
212853582011Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein.38

Citation

Dessen P

CERT1 (ceramide transporter 1)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58122/cert1-(ceramide-transporter-1)