H3-3B (H3.3 histone B)

2019-08-01  

Identity

HGNC
H3-3B
LOCATION
17q25.1
LOCUSID
3021
ALIAS
H3-3A,H3.3B,H3F3B

Other Information

Locus ID:

NCBI: 3021
MIM: 601058
HGNC: 4765
Ensembl: ENSG00000132475

Variants:

dbSNP: 3021
ClinVar: 3021
TCGA: ENSG00000132475
COSMIC: H3-3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132475ENST00000254810P84243
ENSG00000132475ENST00000254810B2R4P9
ENSG00000132475ENST00000586270K7EK07
ENSG00000132475ENST00000586607P84243
ENSG00000132475ENST00000586607B2R4P9
ENSG00000132475ENST00000587171K7ES00
ENSG00000132475ENST00000587560P84243
ENSG00000132475ENST00000587560B2R4P9
ENSG00000132475ENST00000589599P84243
ENSG00000132475ENST00000589599B2R4P9
ENSG00000132475ENST00000591890K7EMV3
ENSG00000132475ENST00000592643K7EP01

Pathways

PathwaySourceExternal ID
Systemic lupus erythematosusKEGGko05322
Systemic lupus erythematosusKEGGhsa05322
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3REACTOMER-HSA-5625886
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Promoter OpeningREACTOMER-HSA-73728
RNA Polymerase I Chain ElongationREACTOMER-HSA-73777
Gene Silencing by RNAREACTOMER-HSA-211000
Transcriptional regulation by small RNAsREACTOMER-HSA-5578749
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
PRC2 methylates histones and DNAREACTOMER-HSA-212300
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
SIRT1 negatively regulates rRNA ExpressionREACTOMER-HSA-427359
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
DNA methylationREACTOMER-HSA-5334118
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Condensation of Prophase ChromosomesREACTOMER-HSA-2299718
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446
Developmental BiologyREACTOMER-HSA-1266738
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
B-WICH complex positively regulates rRNA expressionREACTOMER-HSA-5250924
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionREACTOMER-HSA-427389

References

Pubmed IDYearTitleCitations
380665462023Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies.3
380665462023Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies.3
347824252022Gene of the month: H3F3A and H3F3B.7
347824252022Gene of the month: H3F3A and H3F3B.7
330074282021The histone variant H3.3 regulates the transcription of the hepatitis B virus.9
330074282021The histone variant H3.3 regulates the transcription of the hepatitis B virus.9
321695592020The interaction of histone modification related H3F3B and NSD2 genes increases the susceptibility to schizophrenia in a Chinese population.0
330673962020Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.40
332683562020Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients.34
321695592020The interaction of histone modification related H3F3B and NSD2 genes increases the susceptibility to schizophrenia in a Chinese population.0
330673962020Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.40
332683562020Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients.34
295290982018Validation of a microRNA target site polymorphism in H3F3B that is potentially associated with a broad schizophrenia phenotype.2
298948582018Putative functional SNPs in SLC22A3 and H3F3B might influence the development of CAD by regulating the lipid levels.0
295290982018Validation of a microRNA target site polymorphism in H3F3B that is potentially associated with a broad schizophrenia phenotype.2

Citation

Dessen P

H3-3B (H3.3 histone B)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58123