H3C4 (H3 clustered histone 4)

2019-08-01 Affiliation

Identity

HGNC

H3C4

LOCATION

6p22.2

LOCUSID

8351

ALIAS

H3/b,H3C1,H3C10,H3C11,H3C12,H3C2,H3C3,H3C6,H3C7,H3C8,H3FB,HIST1H3D

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8351
MIM: 602811
HGNC: 4767
Ensembl: ENSG00000197409

Variants:

dbSNP: 8351
ClinVar: 8351
TCGA: ENSG00000197409
COSMIC: H3C4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000197409	ENST00000356476	P68431

Pathways

Pathway	Source	External ID
Systemic lupus erythematosus	KEGG	ko05322
Systemic lupus erythematosus	KEGG	hsa05322
Transcriptional misregulation in cancer	KEGG	ko05202
Transcriptional misregulation in cancer	KEGG	hsa05202
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
Metabolism of proteins	REACTOME	R-HSA-392499
Amyloid fiber formation	REACTOME	R-HSA-977225
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-7 signaling	REACTOME	R-HSA-1266695
Hemostasis	REACTOME	R-HSA-109582
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases activate PKNs	REACTOME	R-HSA-5625740
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	REACTOME	R-HSA-5625886
Signaling by Wnt	REACTOME	R-HSA-195721
TCF dependent signaling in response to WNT	REACTOME	R-HSA-201681
Formation of the beta-catenin:TCF transactivating complex	REACTOME	R-HSA-201722
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	REACTOME	R-HSA-504046
RNA Polymerase I Transcription	REACTOME	R-HSA-73864
RNA Polymerase I Promoter Clearance	REACTOME	R-HSA-73854
RNA Polymerase I Promoter Opening	REACTOME	R-HSA-73728
RNA Polymerase I Chain Elongation	REACTOME	R-HSA-73777
Gene Silencing by RNA	REACTOME	R-HSA-211000
Transcriptional regulation by small RNAs	REACTOME	R-HSA-5578749
Epigenetic regulation of gene expression	REACTOME	R-HSA-212165
PRC2 methylates histones and DNA	REACTOME	R-HSA-212300
Negative epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250941
SIRT1 negatively regulates rRNA Expression	REACTOME	R-HSA-427359
NoRC negatively regulates rRNA expression	REACTOME	R-HSA-427413
DNA methylation	REACTOME	R-HSA-5334118
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Condensation of Prophase Chromosomes	REACTOME	R-HSA-2299718
Meiosis	REACTOME	R-HSA-1500620
Meiotic recombination	REACTOME	R-HSA-912446
Developmental Biology	REACTOME	R-HSA-1266738
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
Oxidative Stress Induced Senescence	REACTOME	R-HSA-2559580
Senescence-Associated Secretory Phenotype (SASP)	REACTOME	R-HSA-2559582
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
HATs acetylate histones	REACTOME	R-HSA-3214847
HDACs deacetylate histones	REACTOME	R-HSA-3214815
HDMs demethylate histones	REACTOME	R-HSA-3214842
PKMTs methylate histone lysines	REACTOME	R-HSA-3214841
RMTs methylate histone arginines	REACTOME	R-HSA-3214858
Positive epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250913
B-WICH complex positively regulates rRNA expression	REACTOME	R-HSA-5250924
Activation of HOX genes during differentiation	REACTOME	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	REACTOME	R-HSA-5617472
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	REACTOME	R-HSA-427389

References

Pubmed ID	Year	Title	Citations
33086884	2020	Fucoxanthin may inhibit cervical cancer cell proliferation via downregulation of HIST1H3D.	6
33086884	2020	Fucoxanthin may inhibit cervical cancer cell proliferation via downregulation of HIST1H3D.	6
28112369	2017	HIST1H3D: A promising therapeutic target for lung cancer.	3
28112369	2017	HIST1H3D: A promising therapeutic target for lung cancer.	3
24097871	2013	Contrasting expression patterns of histone mRNA and microRNA 760 in patients with gastric cancer.	22
24097871	2013	Contrasting expression patterns of histone mRNA and microRNA 760 in patients with gastric cancer.	22

Citation

Dessen P

H3C4 (H3 clustered histone 4)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58131/h3c4-(h3-clustered-histone-4)

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