H3-4 (H3.4 histone)

2019-08-01  

Identity

HGNC
LOCATION
1q42.13
LOCUSID
ALIAS
H3.4,H3/g,H3FT,H3t,HIST3H3

Other Information

Locus ID:

NCBI: 8290
MIM: 602820
HGNC: 4778
Ensembl: ENSG00000168148

Variants:

dbSNP: 8290
ClinVar: 8290
TCGA: ENSG00000168148
COSMIC: H3-4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168148ENST00000366696Q16695

Pathways

PathwaySourceExternal ID
Systemic lupus erythematosusKEGGko05322
Systemic lupus erythematosusKEGGhsa05322
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Condensation of Prophase ChromosomesREACTOMER-HSA-2299718
Chromosome MaintenanceREACTOMER-HSA-73886
Telomere MaintenanceREACTOMER-HSA-157579
Packaging Of Telomere EndsREACTOMER-HSA-171306
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446
Meiotic synapsisREACTOMER-HSA-1221632
DNA RepairREACTOMER-HSA-73894
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571

References

Pubmed IDYearTitleCitations
350218532022The unfavorable clinical outcome of COVID-19 in smokers is mediated by H3K4me3, H3K9me3 and H3K27me3 histone marks.6
350218532022The unfavorable clinical outcome of COVID-19 in smokers is mediated by H3K4me3, H3K9me3 and H3K27me3 histone marks.6
338052012021Detection of H3K4me3 Identifies NeuroHIV Signatures, Genomic Effects of Methamphetamine and Addiction Pathways in Postmortem HIV+ Brain Specimens that Are Not Amenable to Transcriptome Analysis.5
341013542021Matrix metalloproteinase-2 mediates ribosomal RNA transcription by cleaving nucleolar histones.12
338052012021Detection of H3K4me3 Identifies NeuroHIV Signatures, Genomic Effects of Methamphetamine and Addiction Pathways in Postmortem HIV+ Brain Specimens that Are Not Amenable to Transcriptome Analysis.5
341013542021Matrix metalloproteinase-2 mediates ribosomal RNA transcription by cleaving nucleolar histones.12
294051692018An association study of the single-nucleotide polymorphism c190C>T (Arg64Cys) in the human testis-specific histone variant, H3t, of Japanese patients with Sertoli cell-only syndrome.2
294572922018Antibodies against H3 and H4 histones from the sera of HIV-infected patients catalyze site-specific degradation of these histones.20
296102792018H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation.49
299324192018H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers.49
305320242018Transcriptome and protein interaction profiling in cancer cells with mutations in histone H3.3.2
294051692018An association study of the single-nucleotide polymorphism c190C>T (Arg64Cys) in the human testis-specific histone variant, H3t, of Japanese patients with Sertoli cell-only syndrome.2
294572922018Antibodies against H3 and H4 histones from the sera of HIV-infected patients catalyze site-specific degradation of these histones.20
296102792018H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation.49
299324192018H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers.49

Citation

Dessen P

H3-4 (H3.4 histone)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58148/h3-4-(h3-4-histone)