Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2058
MIM: 138295
HGNC: 3418
Ensembl: ENSG00000136628
Variants:
dbSNP: 2058
ClinVar: 2058
TCGA: ENSG00000136628
COSMIC: EPRS1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000136628 | ENST00000366923 | P07814 |
| ENSG00000136628 | ENST00000477030 | V9GZ76 |
| ENSG00000136628 | ENST00000609181 | V9GYZ6 |
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38320721 | 2024 | Glutamyl-prolyl-tRNA synthetase (EPRS1) drives tubulointerstitial nephritis-induced fibrosis by enhancing T cell proliferation and activity. | 0 |
| 38769304 | 2024 | Homozygous EPRS1 missense variant causing hypomyelinating leukodystrophy-15 alters variant-distal mRNA m(6)A site accessibility. | 0 |
| 38320721 | 2024 | Glutamyl-prolyl-tRNA synthetase (EPRS1) drives tubulointerstitial nephritis-induced fibrosis by enhancing T cell proliferation and activity. | 0 |
| 38769304 | 2024 | Homozygous EPRS1 missense variant causing hypomyelinating leukodystrophy-15 alters variant-distal mRNA m(6)A site accessibility. | 0 |
| 36631435 | 2023 | Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma. | 4 |
| 36631435 | 2023 | Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma. | 4 |
| 34537243 | 2021 | Disease-associated mutations in a bifunctional aminoacyl-tRNA synthetase gene elicit the integrated stress response. | 11 |
| 34537243 | 2021 | Disease-associated mutations in a bifunctional aminoacyl-tRNA synthetase gene elicit the integrated stress response. | 11 |
| 32611237 | 2020 | Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-Fibrotic Protein Synthesis During Cardiac Fibrosis. | 38 |
| 32611237 | 2020 | Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-Fibrotic Protein Synthesis During Cardiac Fibrosis. | 38 |
| 29576217 | 2018 | Bi-allelic Mutations in EPRS, Encoding the Glutamyl-Prolyl-Aminoacyl-tRNA Synthetase, Cause a Hypomyelinating Leukodystrophy. | 45 |
| 29643180 | 2018 | Structural control of caspase-generated glutamyl-tRNA synthetase by appended noncatalytic WHEP domains. | 7 |
| 29576217 | 2018 | Bi-allelic Mutations in EPRS, Encoding the Glutamyl-Prolyl-Aminoacyl-tRNA Synthetase, Cause a Hypomyelinating Leukodystrophy. | 45 |
| 29643180 | 2018 | Structural control of caspase-generated glutamyl-tRNA synthetase by appended noncatalytic WHEP domains. | 7 |
| 27612429 | 2016 | EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer. | 28 |
Citation
Dessen P
EPRS1 (glutamyl-prolyl-tRNA synthetase 1)
Atlas Genet Cytogenet Oncol Haematol. 2019-08-01
Online version: http://atlasgeneticsoncology.org/gene/58163/chromosome-explorer/submit-meetings/
